Heart Transplantation Mortality in Recipients with Muscular Dystrophy

We want to compare mortality in heart transplant (HTx) recipients with and without Muscular Dystrophy.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (722) Source Type: research

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UCLA researchers are part of an international team that reported the use of a stem cell gene therapy to treat nine people with the rare, inherited blood disease known as X-linked chronic granulomatous disease, or X-CGD. Six of those patients are now in remission and have stopped other treatments. Before now, people with X-CGD – which causes recurrent infections, prolonged hospitalizations for treatment, and a shortened lifespan – had to rely on bone marrow donations for a chance at remission.“With this gene therapy, you can use a patient’s own stem cells instead of donor cells for a transplant,&rdqu...
Source: UCLA Newsroom: Health Sciences - Category: Universities & Medical Training Source Type: news
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Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
As survival and neuromuscular function in Duchenne Muscular Dystrophy (DMD) have improved with glucocorticoid therapy and advances in respiratory care, the proportion of cardiac deaths is increasing. Little is known about risk factors for cardiac causes of death in this population.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 264 Source Type: research
Patients with muscular dystrophy may have an associated cardiomyopathy, resulting in advanced heart failure requiring transplantation. However, the skeletal muscle dysfunction can result in respiratory impairment, dysphagia, and inability to participate in rehabilitation after heart transplantation. The purpose of this study was to describe the characteristics and outcomes of muscular dystrophy patients undergoing heart transplantation at our center.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 997 Source Type: research
There is variable practice and debate surrounding prophylactic heart failure (HF) therapy in Duchenne Muscular Dystrophy (DMD) patients with normal systolic function. We sought to determine the impact of HF medications including ACE inhibitors and ARB on the development of moderate systolic dysfunction or death in a cohort of DMD patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1177 Source Type: research
Current guidelines for the management of left ventricular systolic dysfunction (LVSD) in Duchenne Muscular Dystrophy (DMD) recommend angiotensin converting enzyme (ACE) inhibitors (class IIa). Little is known about the historic use of HF medications in Duchenne Muscular Dystrophy (DMD) and LVSD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1176 Source Type: research
Little is known about sudden cardiac death risk and arrhythmias in boys with Duchenne muscular dystrophy(DMD). The goal of the study is to describe ECG findings and arrhythmia burden in a multi-center contemporary cohort of boys with DMD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1174 Source Type: research
Duchenne muscular dystrophy (DMD) is characterized by myocardial fibrosis and left ventricular (LV) dysfunction. Implantable cardioverter defibrillator (ICD) use has not been characterized in this population but is generally considered for patients with severe LV dysfunction receiving goal directed medical therapy (GDMT), including a beta blocker plus an angiotensin converting enzyme inhibitor. We evaluated utilization and efficacy of ICD use in patients with DMD.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: 1171 Source Type: research
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Significant genetic heterogeneity exists in the dystrophin gene in males with Duchenne Muscular Dystrophy (DMD). The goal is to describe the impact of genetic variations on clinical outcomes.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Source Type: research
More News: Cardiology | Heart | Heart Transplant | Lung Transplant | Muscular Dystrophy | Reflex Sympathetic Dystrophy | Transplant Surgery | Transplants