Effect of High-Intensity Interval Training in De Novo Heart Transplant Recipients - 3-year Results from the HITTS Randomized Controlled Trial

The HITTS study (High -intensity Interval Training in de novo Heart Transplant Recipients in Scandinavia) is a randomized controlled trial designed to assess the effect of high-intensity interval training (HIT) versus moderate intensity continuous training (MICT) on exercise capacity in de novo heart transplant recipients. The primary endpoint was the change in oxygen consumption (VO2peak) at the end of the intervention period, which began 3 months after heart transplantation (HTx). After the 9-month long intervention period, we reported a between-group difference in VO2peak of 1.8 ml/kg/min in favor of HIT (p  = 0.04).We found that HIT was safe, well tolerated and efficient.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (539) Source Type: research

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We previously developed a post LVAD mortality prediction model using multicenter data incorporating pectoralis muscle mass and tissue attenuation obtained on preoperative CT scans. The purpose of this analysis was to evaluate the performance of this model in a prospective cohort including the most contemporary LVADs.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (66) Source Type: research
Cardiac cachexia with associated sarcopenia and frailty has been associated with adverse outcomes after placement of a durable left ventricular assist device (LVAD). The purpose of this study is to examine whether the pectoralis muscle index (PMI) measured from preoperative CT scans of the chest will predict outcomes after LVAD implantation.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (863) Source Type: research
Hepatic cirrhosis is a potential severe complication of chronic heart failure and has major implications on treatment options. In general, patients with cirrhosis are considered ineligible for isolated cardiac transplantation. Therefore, proper diagnosis of cirrhosis is paramount. The aim of this retrospective study is to explore the diagnostic value of abdominal ultrasound, hepatosplenic scan and abdominal computed tomography scan (CT scan) for liver disease secondary to advanced heart failure.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (564) Source Type: research
CytoSorb treatment is a promising tool to treat severe inflammatory status in the acute care setting. Its effect on drugs is, however, poorly documented in vivo, although unselective and unpredictable removal of small molecules might translate into decreased blood levels of potentially life-saving medications. The aim of this study was to assess the impact of Cytosorb treatment on clereance of small drug molecules, measured as dose adjustements need, in a large population of critically ill patients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1303) Source Type: research
High-intensity interval training (HIT) is an effective method to increase exercise capacity in de novo heart transplant recipients, as shown in the recently published HITTS study (High-intensity Interval Training in de novo Heart Transplant recipients in Scandinavia). We were interested to scrutinize the potential effect of HIT in different age categories. The main effects of HIT in one young and one older medically stable de novo heart transplant recipients are reported.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1260) Source Type: research
Cardiac allograft vasculopathy (CAV) is a major cause of morbidity and mortality post heart transplant (HT). Coronary calcium has a sensitivity of 91% for the presence of>50% angiographic stenosis among the general population. Given the different pathophysiology of CAV and atherosclerosis, it is unclear whether visually estimated coronary artery calcification (VECAC) on CT attenuation correction (CTAC) scans can be used to detect CAV post HT and whether there is an association with long-term outcomes in patients with CAV.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (599) Source Type: research
Donor shortage remains a major obstacle associated with considerable mortality in patients waiting for lung transplantation (LTx). Objective donor lung assessment is crucial to obtain sufficient grafts of acceptable quality. We hypothesized that out of body chest CT may be an innovative way to assess grafts prior to LTx. Therefore, this study prospectively investigated the value of CT scan of donor lungs prior to LTx.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (328) Source Type: research
Coronary allograft vasculopathy (CAV) following heart transplantation (HT) is a major cause of morbidity and mortality. Assessment of myocardial flow reserve (MFR) by positron emission tomography (PET) is increasingly used in clinical practice; reduced MFR has been associated with adverse cardiovascular (CV) outcomes. Little is known regarding sex differences in MFR and associated outcomes in HT recipients.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (604) Source Type: research
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