Heart Transplantation Outcomes in Patients with Marfan Syndrome: UNOS Registry Analysis

Marfan syndrome (MS) is an autosomal dominant connective tissue disorder that causes a defect in the gene fibrillin-1. MS patients develop advanced cardiomyopathies, in which previous studies have demonstrated the presence of a discrete cardiomyopathy associated with MS. Given the vascular complications associated with MS and unclear impact immunosuppression may have on systemic vascular disease, little evidence guides suitability of patients with MS for heart transplant. We sought to investigate long-term heart transplant outcomes of patients with MS listed in the UNOS registry.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: P.A. Genyk, J. Nattiv, G.S. Liu, P. Banankhah, P.A. Kingsford, J.P. Li, A.M. Wolfson, D. Vucicevic, A.S. Vaidya, E.C. DePasquale Tags: (540) Source Type: research