Pulmonary Microbiome Changes in Lung Transplant Recipients with Gastroesophageal Reflux

The pulmonary microbiome modulates the immune milieu in the lung allograft and is in turn influenced by external factors such as microaspiration of oropharyngeal contents. A potential driver of microaspiration is gastroesophageal reflux disease (GERD), which has been associated with poor outcomes after lung transplantation. We aimed to compare the pulmonary microbiome in lung transplant recipients with and without GERD, and correlate microbial composition with concurrent lung inflammation.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: C. Zhang, P.H. Schneeberger, L. Levy, Y. Lee, E. Huszti, S.E. Hunter, M. Ahmed, S. Moshkelgosha, K. Boonstra, A.T. Sage, P. Shah, M. Budev, S.S. Weigt, J. Belperio, L. Snyder, J.L. Todd, J. Reynolds, S. Palmer, J. Yeung, L.G. Singer, S. Keshavjee, B. Cobu Tags: (233) Source Type: research