Depressive Symptoms in Lung Transplant Recipients: Trajectory and Association with Mortality

Prior studies suggest an association between elevated depressive symptoms following lung transplant (LT) and mortality. We sought to test this association using a longitudinal cohort with 3-years of follow up, and to determine the long-term impact of LT on depressive symptoms.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (282) Source Type: research

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This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function. On Nutraceutical Senolytics https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/ Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Donors of death due to anoxic brain injury such as suicidal hanging are at risk for a severe catecholamine surge leading to an acute myocardial stress that can cause global tissue hypoxia as well as pulmonary edema and barotrauma, all of which may potentially adversely impact myocardial tissue. Concerns have been raised about potential higher rates of Primary Graft Dysfunction (PGD) in heart transplant recipients of such donors due to this acute myocardial stressor. We wanted to assess if this mechanism of donor death does carry an increased risk of PGD or other adverse outcomes in our single center experience.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (739) Source Type: research
Cognitive impairment and mood deviation often occurs in patients with heart failure. Frailty and sarcopenia have been widely studied in patients with heart disease, but cognitive frailty has been little explored. High complexity of patients referred for heart transplantation connected with socioeconomic characteristics in a developing country underlines the importance to investigate cognitive and mood conditions in this population. The aim of the study is to evaluate the prevalence of cognitive impairment and depression symptoms in patients with heart failure in waiting list for heart transplantation (HTx).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (571) Source Type: research
Burnout is common in all types of physicians, but little is known about burnout in lung transplant physicians. The purpose of this study was to explore burnout and its relationship to job factors and depression in lung transplant physicians.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (389) Source Type: research
Left ventricular assist devices (LVAD) are being implanted at a higher rate than ever before to treat end stage heart failure, and are known to decrease mortality and increase quality of life (QOL) for patients. However, major adverse events, including major bleeding and infection (INTERMACS definitions), are common in patients with an LVAD. These events have great potential to impair patient experiences of living with an LVAD.The purpose of this analysis was to examine whether having a major adverse event would alter patient-reported outcomes over time, including depressive symptoms and QOL.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1274) Source Type: research
In this study we sought to examine outcomes in recipients stratified by donor brain death related to underlying donor disease vs brain death that was independent of any underlying donor disease (including trauma, suicide, drug overdose, and others).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (648) Source Type: research
Severe lung disease may have significant effects on mental health, which may be exacerbated by the stress of awaiting lung transplantation (LTx). However, the prevalence of depression and anxiety symptoms in LTx candidates and the effects of these disorders on health-related quality of life (HRQL) has not been well described. We sought to describe the prevalence of depression and anxiety in patients on the LTx waiting list, and associations between depression or anxiety symptoms and HRQL.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (985) Source Type: research
Reported outcomes after left ventricular assist device (LVAD) implant include mortality, hospital readmission and severe adverse events. We have less information about patients ’ perceptions of their quality of life (QOL) after hospital discharge. We conducted a prospective two-center international pilot study to assess anxiety, depression and post-traumatic stress disorder (PTSD) following LVAD implant as bridge to transplant (BTT) or destination therapy (DT).
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (1105) Source Type: research
Health literacy is an established concept in the health care world that seeks to understand people's comprehension of various healthcare information and their ability to apply it. Health literacy has been extensively studied in the heart failure literature, and inadequate health literacy has been linked to impaired ability to assess risk versus benefit information, poorer physical and mental health, increased hospitalizations, and an inability to fully engage in treatment planning and self-care.
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: (74) Source Type: research
In conclusion, taller body height at the entry to adulthood, supposed to be a marker of early-life environment, is associated with lower risk of dementia diagnosis later in life. The association persisted when adjusted for educational level and intelligence test scores in young adulthood, suggesting that height is not just acting as an indicator of cognitive reserve. A Comparison of Biological Age Measurement Approaches https://www.fightaging.org/archives/2020/02/a-comparison-of-biological-age-measurement-approaches/ Researchers here assess the performance of a range of approaches to measuring biological...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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