Should Pre-Transplant Esophageal Dysmotility Preclude Candidacy for Lung Transplantation?
Esophageal dysmotility can decrease luminal clearance and increase the risk of aspiration and GERD and contribute to allograft dysfunction. We sought to determine the impact of pre-transplant esophageal dysmotility on allograft function, GERD, rejection and survival after lung transplantation.
ConclusionRobotically assisted Heller myotomy and POEM are safe and efficacious treatments for achalasia with lower rates of technical complications compared to laparoscopic Heller myotomy. With the advancements in endoscopic instruments and robotic surgery, POEM and robotically assisted Heller myotomy should be considered in the treatment of achalasia and esophageal dysmotility disorders.
Enteric neuronal degeneration, as seen in inflammatory bowel disease, obesity, and diabetes, can lead to gastrointestinal dysmotility. Pyroptosis is a novel form of programmed cell death but little is known about its role in enteric neuronal degeneration. We observed higher levels of cleaved caspase-1, a marker of pyroptosis, in myenteric ganglia of overweight and obese human subjects compared with normal-weight subjects. Western diet–fed (WD-fed) mice exhibited increased myenteric neuronal pyroptosis, delayed colonic transit, and impaired electric field stimulation–induced colonic relaxation responses. WD incr...
Peroral endoscopic myotomy (POEM) in patients with esophageal dysmotility who have previously undergone bariatric surgery can be challenging due to extensive adhesions and altered anatomy. Outcomes of POEM in patients with prior bariatric surgeries has not been well studied. The aim of the study was to analyze the outcomes of POEM in management of esophageal dysmotility in patients who have previously undergone bariatric surgeries.
The first step in the Chicago Classification v3.0 of esophageal dysmotility disorders (EDD) is to determine if the integrated relaxation pressure (IRP) decreases appropriately signifying appropriate LES relaxation. Although the diagnosis is based on HRM, impedance planimetry may be a useful tool to guide management in challenging cases.
Publication date: August 2020Source: Journal of Functional Foods, Volume 71Author(s): Sakena K-da, Saranya Peerakietkhajorn, Brenda Siringoringo, Paradorn Muangnil, Santad Wichienchot, Pissared Khuituan
Abstract BACKGROUND: Infants with gastroschisis require operations and lengthy hospitalizations due to intestinal dysmotility. Dysbiosis may contribute to these problems. Little is known on the microbiome of gastroschisis infants. METHODS: The purpose of this study was to investigate the fecal microbiome in gastroschisis infants. Microbiome profiling was performed by sequencing the V4 region of the 16S rRNA gene. The microbiome of gastroschisis infants was compared to the microbiome of healthy controls, and the effects of mode of birth delivery, gestational age, antibiotic duration, and nutrition type on micr...
AbstractGastroparesis is a common symptom in Parkinson ’s disease (PD) and whether any change occurs in gastric smooth muscle cells (SMCs) of PD patients is unclear. We previously reported that rats with bilateral substantia nigra lesions induced by 6-hydroxydopamine (6-OHDA), referred to as 6-OHDA rats, manifest typical gastroparesis. In the present study, we further investigate the underlying mechanism. By means of an organ bath system and an implantable radiotelemetry system, both a weakened contractile force of gastric circular smooth muscle and gastric myoelectric activity were detected in the 6-OHDA rats and ph...
The newest addition in the management of achalasia and esophagogastric junction outflow obstruction (EGJOO) is a 30 mm hydrostatic balloon dilator that uses impedance planimetry technology. It allows for the measurement of the diameter and cross-sectional area to determine effective dilation. We aimed to (1) determine the clinical success (defined as a decrease in Eckardt score to ≤3) in the treatment of esophageal motility disorders; (2) report the safety (rate/severity of adverse events (AEs)).
Hirschsprung disease (HSCR) is characterized by distal intestinal aganglionosis. While surgery is lifesaving, gastrointestinal (GI) motility disorders persist in many patients. Our objective was to determine whether enteric nervous system (ENS) abnormalities exist in the ganglionated portions of the GI tract far proximal to the aganglionic region and whether these are associated with GI dysmotility.