A Novel Pseudomonas aeruginosa Virulence Factor Predicts CLAD and Death after Lung Transplantation

Gram -ve bacteria have recently been found to induce O-antigen-specific IgG2 and IgA ‘inhibitory’ antibodies (iAb) in the host which are not only impotent but block complement-mediated killing. Our group has demonstrated the clinical benefit of plasmapheresis in patients infected with Pseudomonas aeruginosa (Psa) strains which have deployed this virulence factor. Here we assesse d the prevalence and clinical impact of iAb in a large lung transplant cohort.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: C. Divithotawela, A. Pham, E.L. Ledger, P. Hopkins, M. Tan, S. Yerkovich, T.J. Wells, D.C. Chambers Tags: (137) Source Type: research