Decreased Immune Activation in Cystic Fibrosis Airway Epithelium Following Lung Transplant

End-stage cystic fibrosis (CF) can be managed by lung transplantation (LT), but chronic allograft dysfunction (CLAD) limits long-term survival. While Pseudomonas aeruginosa airway infection (PsA) is a risk factor for CLAD for most lung allograft recipients, this association does not hold for CF recipients. We hypothesized that differences in host epithelial immune responses and the composition of airway microbial communities could contribute to protection from CLAD in CF recipients with PsA.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: D.T. Dugger, M. Fung, L. Zlock, S. Caldera, S.R. Hays, J.P. Singer, L.E. Leard, J.A. Golden, R. Shah, J. Kukreja, W. Finkbeiner, M. Kleinhenz, C. Langelier, J.R. Greenland Tags: (139) Source Type: research