Characterization of a Novel CD8+ B Cell Subset in Monkeys Tolerant of Heart Allografts

We have previously reported that transient mixed hematopoietic chimerism induced via donor bone marrow transplantation can achieve tolerance to cardiac allografts in non-human primates (NHPs). The purpose of this study was to measure the frequency and properties of a unique subset of CD8+ B cells, recently identified in our laboratory, in tolerant monkeys.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: J.A. Morrissette, K. Pruner, S. Lee, J. Paster, W. Sommer, J. O, I. Hanekamp, P. Sage, G. Benichou, J.C. Madsen Tags: (195) Source Type: research