Cangrelor with Heparin for Patients with Heparin-Induced Thrombocytopenia Undergoing Pulmonary Thromboendarterectomy

Optimal intraoperative anticoagulation strategy for patients with heparin-induced thrombocytopenia (HIT) undergoing pulmonary thromboendarterectomy (PTE) that necessitates deep hypothermic circulatory arrest (DHCA) remains controversial. Cangrelor is an intravenous direct-acting P2Y12 platelet receptor antagonist that achieves therapeutic effect and eliminates rapidly. Its antiplatelet activity is unaffected by stagnation of blood, nor is it influenced by patient's age, renal status or hepatic function.

Source: The Journal of Heart and Lung Transplantation - March 31, 2020 Category: Transplant Surgery Authors: Y.K. Gernhofer, C.Y. Lee, D.A. Banks, N.H. Kim, M.M. Madani, V. Pretorius Tags: (1325) Source Type: research