Mechanisms and Points of Control in the Spread of Inflammation: A Mathematical Investigation.

Mechanisms and Points of Control in the Spread of Inflammation: A Mathematical Investigation. Bull Math Biol. 2020 Mar 28;82(4):45 Authors: Bayani A, Dunster JL, Crofts JJ, Nelson MR Abstract Understanding the mechanisms that control the body's response to inflammation is of key importance, due to its involvement in myriad medical conditions, including cancer, arthritis, Alzheimer's disease and asthma. While resolving inflammation has historically been considered a passive process, since the turn of the century the hunt for novel therapeutic interventions has begun to focus upon active manipulation of constituent mechanisms, particularly involving the roles of apoptosing neutrophils, phagocytosing macrophages and anti-inflammatory mediators. Moreover, there is growing interest in how inflammatory damage can spread spatially due to the motility of inflammatory mediators and immune cells. For example, impaired neutrophil chemotaxis is implicated in causing chronic inflammation under trauma and in ageing, while neutrophil migration is an attractive therapeutic target in ailments such as chronic obstructive pulmonary disease. We extend an existing homogeneous model that captures interactions between inflammatory mediators, neutrophils and macrophages to incorporate spatial behaviour. Through bifurcation analysis and numerical simulation, we show that spatially inhomogeneous outcomes can present close to the switch from bistability to guaranteed resolution in...
Source: Bulletin of Mathematical Biology - Category: Bioinformatics Authors: Tags: Bull Math Biol Source Type: research

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In conclusion, this study suggests that epigenetic age acceleration is significantly associated with lung function in women older than 50 years. We hypothesised that this could be due to menopause. However, we have observed that menopause has minimal effect and therefore there is possibility of other unknown physiological factors at older age in females mediating the epigenetic age acceleration effect on lung function. While, it is still unknown what exactly epigenetic aging from DNA methylation measures, this study suggests it can be utilised as one of the important factors to assess women's lung health in old age. DNA me...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study evaluated the effects of dried ginger and LGWWJX decoction on cold asthma at the metabolomics level. It provides a reference for the research on the compatibility of Chinese Medicine. Introduction Ginger is a Chinese medicine (CM) used as a food and as a medicine, and is often used to treat cold syndrome through the property of warming. Dried ginger (Zingiberis Rhizoma, GanJiang, GJ) is processed from fresh ginger and is also commonly used in CM. It is used to treat cold asthma by “warming the stomach to dispel cold, warming the lung to resolve fluid,” and it has significant anti-inflammatory...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
The objective of our study was to investigate the prevalence of analgesic use in community‐dwelling persons with and without Alzheimer's disease (AD), within six months after AD diagnosis and to find out factors associated with the use of analgesics and specific analgesic groups. MethodWe utilized data from register based MEDALZ (Medication use and Alzheimer's disease) cohort consisting of all community‐dwelling persons diagnosed with AD during 2005–2011 in Finland and their matched comparison persons without AD. Altogether, 67,215 persons with AD and one comparison person for each case were included. Drug use da...
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research
Conditions:   Hypertension;   Depression;   Anxiety;   Musculoskeletal Pain;   Arthritis;   Rheumatoid Arthritis;   Osteoporosis;   Chronic Obstructive Pulmonary Disease (COPD);   Asthma;   Chronic Bronchitis;   Cardiovascular Disease;   Heart Failure;   Stroke;   Transient Ischemic Attacks;   Ulcer;   Gastroesophageal Reflux;   Irritable Bowel;   Crohn's Disease;   Ulcerative Colitis;   Diverticulosis;   Chronic Hepatitis;   Diabetes; ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Hypertension;   Depression;   Anxiety;   Musculoskeletal Pain;   Arthritis;   Rheumatoid Arthritis;   Osteoporosis;   Chronic Obstructive Pulmonary Disease (COPD);   Asthma;   Chronic Bronchitis;   Cardiovascular Disease;   Heart Failure;   Stroke;   Transient Ischemic Attacks;   Ulcer;   Gastroesophageal Reflux;   Irritable Bowel;   Crohn's Disease;   Ulcerative Colitis;   Diverticulosis;   Chronic Hepatitis;   Diabetes; ...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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