β < sub > 3 < /sub > -Adrenoceptor redistribution impairs NO/cGMP/PDE2 signalling in failing cardiomyocytes

In conclusion, topographic and functional reorganization of the b3-AR/cGMP signalosome happens in heart failure and should be considered when designing new therapies acting via this receptor.
Source: eLife - Category: Biomedical Science Tags: Cell Biology Source Type: research