Evidence for a pathogenic role of extrafollicular, IL-10-producing CCR6+B helper T cells in systemic lupus erythematosus [Immunology and Inflammation]

Interleukin 10 (IL-10) is an antiinflammatory cytokine, but also promotes B cell responses and plays a pathogenic role in systemic lupus erythematosus (SLE). CD4+CCR6+IL-7R+T cells from human tonsils produced IL-10 following stimulation by naïve B cells, which promoted B cell immunoglobulin G (IgG) production. These tonsillar CCR6+B helper T cells...

Source: Proceedings of the National Academy of Sciences - March 30, 2020 Category: Science Authors: F. Facciotti, P. Larghi, R. Bosotti, C. Vasco, N. Gagliani, C. Cordiglieri, S. Mazzara, V. Ranzani, E. Rottoli, S. Curti, A. Penatti, B. Karnani, Y. Kobayashi, M. Crosti, M. Bombaci, J. P. van Hamburg, G. Rossetti, R. Gualtierotti, M. Gerosa, S. Gatti, S. Tags: Biological Sciences Source Type: research