Severe cases of BCGosis-susceptible PID identified by next-generation sequencing: Implications for adjustment of BCG vaccination timing in China

Publication date: Available online 30 March 2020Source: Journal of Genetics and GenomicsAuthor(s): Gang Liu, Haijuan Xiao, Linlin Liu, Lingyun Guo, Ruolan Guo, Xuyun Hu, Chanjuan Hao, Jingang Gui, Weiwei Jiao, Fang Xu, Adong Shen, Wei Li
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research

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Publication date: Available online 30 March 2020Source: Journal of Genetics and GenomicsAuthor(s): Gang Liu, Haijuan Xiao, Linlin Liu, Lingyun Guo, Ruolan Guo, Xuyun Hu, Chanjuan Hao, Jingang Gui, Weiwei Jiao, Fang Xu, Adong Shen, Wei Li
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
CONCLUSIONS: This new disease is pushing the scientific community to develop swiftly a safe and effective vaccine. Notwithstanding the limitations of our analysis, given by the absence of available results, we try to provide a comprehensive view of the ongoing clinical trials in humans. Our analysis reveals a worldwide effort of both scientists and enterprises to achieve one of the most challenging goals of our century. PMID: 32456404 [PubMed - as supplied by publisher]
Source: Panminerva Medica - Category: General Medicine Tags: Panminerva Med Source Type: research
Source: BMJ Comments - Category: General Medicine Source Type: forums
par I Abstract Chagas disease caused by the hemoflagelate parasite Trypanosoma cruzi is one of the most prevalent endemic parasitosis affecting 7-8 millions of people. Due to the complexity of the infection, no vaccines are available up to now. The extraordinary adjuvant capacity of BCG was explored in this work to develop a vaccine candidate to protect against Trypanosoma cruzi infection by using recombinant BCG vaccine platform. Three antigens of the parasite corresponding to an N and a C terminal fragments of the enzyme trans-sialidase (NT-TS and CT-TS respectively) and a fragment of the enzyme Cruzipain (CZf) ...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research
[UCT] Researchers from the South African Tuberculosis Vaccine Initiative (SATVI) at the University of Cape Town (UCT), the Center for Global Infectious Disease Research - Seattle in the United States, and a large consortium of collaborators have developed a validated a new, simple blood-based test that has the potential to serve multiple functions in the fight against TB.
Source: AllAfrica News: Tuberculosis - Category: Infectious Diseases Source Type: news
Buruli ulcer (BU) is a neglected, tropical infectious disease of the skin and the subcutaneous tissue caused by Mycobacterium ulcerans. This pathogen has emerged as a new species from a common ancestor with Mycobacterium marinum by acquisition of the virulence plasmid pMUM. The plasmid encodes enzymes required for the synthesis of the macrolide toxin mycolactone, which has cytotoxic and immunosuppressive activities. In advanced BU lesions, extracellular clusters of M. ulcerans reside in necrotic subcutaneous tissue and are protected from infiltrating leukocytes by the cytotoxic activity of secreted mycolactone. Several lin...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In this study, we examine the effect of intradermal vaccination with Mycobacterium bovis bacille Calmette-Guèrin on macrophage phenotype following intranasal challenge with virulent Mycobacterium bovis. Preserved lung tissues used in the present study were obtained from a previous vaccination trial in BALB/c mice. Vaccinated mice showed less extensive pulmonary lesions along with a significant decrease in bacterial lung burden when compared to control mice. Immunohistochemical markers of classically activated macrophages (iNOS) and alternatively activated macrophages (Arg1, FIZZ1) were applied to lung sections. Vacc...
Source: Vaccine - Category: Allergy & Immunology Authors: Tags: Vaccine Source Type: research
This study aims to estimate postpartum use of outpatient health services and verify the demographic, socioeconomic, and obstetric factors associated with use. A nationwide hospital-based study in 2011-2012 interviewed 23,894 women. Point estimates and respective confidence intervals were calculated for eight indicators of health services use, with performance assessed as "satisfactory" (75%-100%); "partial" (50%-74%), or "unsatisfactory" (
Source: Cadernos de Saude Publica - Category: International Medicine & Public Health Authors: Tags: Cad Saude Publica Source Type: research
The generation of enduring protective immunity by vaccines is of utmost importance. Intriguingly, there is considerable variation in the efficacy of vaccines amongst individuals. Various studies have shown that normal flora of gastrointestinal tract plays a vital role in maintaining host homeostasis and immunity. Since gut microbiome is also extremely variable between individuals, we speculate that it might impact individual’s response to vaccines. Consequently, we administered broad spectrum antibiotics cocktail to induce gut dysbiosis and monitored its impact on the generation of long-lasting memory T cells and the...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Publication date: 16 May 2020Source: New Scientist, Volume 246, Issue 3282Author(s):
Source: New Scientist - Category: Science Source Type: research
More News: China Health | Genetics | Tuberculosis (BCG) Vaccine | Vaccines