Yale findings expand understanding of fertility after chemotherapy

Chemotherapy for breast cancer negatively impacts a woman ’s fertility after treatment — especially women with a cancer-causing BRCA mutation.
Source: Yale Science and Health News - Category: Universities & Medical Training Source Type: news

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This study shows the complexity of genetic variation in predicting outcomes to treatment. We advocate for future replicative studies to potentially validate GSTA1 and CYP2C19 and definitively negate CYP3A4 and GSTP1 as biomarkers for risk of CROF after cyclophosphamide treatment. Understanding genetic variation in chemotherapy metabolism has the potential to individualise treatment regimens to maximise efficacy and minimise toxicity. PMID: 32496149 [PubMed - as supplied by publisher]
Source: Journal of Obstetrics and Gynaecology - Category: OBGYN Tags: J Obstet Gynaecol Source Type: research
Authors: Macruz CF, Lima SMRR, Postigo S, Martins MM, Lucarelli AP, de Oliveira VM Abstract OBJECTIVE: To assess quality of life and climacteric symptoms for post-menopausal women receiving hormone therapy for breast cancer. METHODS: A prospective observational study of women treated at the Mastology Outpatient Clinic of the Department of Obstetrics and Gynecology was conducted between 2015 and 2019. Post-menopausal patients who had been diagnosed with breast cancer and who were experiencing climacteric symptoms were selected. These patients had undergone surgery, radiotherapy, and/or chemotherapy more than one...
Source: Journal of Obstetrics and Gynaecology Canada : JOGC - Category: OBGYN Tags: J Obstet Gynaecol Can Source Type: research
Condition:   HER2-positive Breast Cancer Interventions:   Drug: Docetaxel;   Drug: Carboplatin;   Drug: Trastuzumab;   Drug: Pertuzumab;   Drug: Trastuzumab emtansine Sponsor:   University of Rochester Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Breast Cancer;   Chemotherapy Effect Interventions:   Drug: Simvastatin 40mg;   Drug: Placebo oral capsule Sponsor:   Indonesia University Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Mind jumble: Understanding chemo brain (Stanford Medicine): Sarah Liu was treated for leukemia as a teenager. She attended her high school graduation on a four-hour pass from Lucile Packard Children’s Hospital Stanford and was bald under her white graduation cap, her arm bandaged where she’d been receiving chemotherapy drugs. Liu survived cancer and the ordeal of her treatment, and for many years she thrived. But today, at 53, she struggles to remember the names of all the Stanford oncologists who helped her, though she reveres them for saving her life. Many years later, her childhood cancer treatments — ...
Source: SharpBrains - Category: Neuroscience Authors: Tags: Cognitive Neuroscience Health & Wellness Technology astrocyte chemo-brain chemobrain chemotherapy chemotherapy-related cognitive impairment cognitive difficulties Cognitive-impairment microglia myelin oligodendrocyte OPC Source Type: blogs
Authors: Tsujinaga S, Iwano H, Oshino T, Kadosaka T, Mizuguchi Y, Motoi K, Chiba Y, Koya T, Temma T, Kamiya K, Fukushima A, Koizumi T, Sato T, Takenaka S, Tada A, Ishizaka S, Sarashina M, Omote K, Kamada R, Konishi T, Sato T, Nagai T, Yamashita H, Anzai T Abstract Epirubicin-based chemotherapy carries a risk of inducing heart failure, although the frequency is rare. Bevacizumab, an anti-vascular endothelial growth factor monoclonal antibody, has recently been widely used in patients with recurrent breast cancer as a first-line chemotherapeutic agent. Heart failure or arterial thromboembolism has been reported as a ...
Source: Internal Medicine - Category: Internal Medicine Tags: Intern Med Source Type: research
Immune response to a given antigen, particularly in cancer patients, is complex and is controlled by various genetic and environmental factors. Identifying biomarkers that can predict robust response to immunization is an urgent need in clinical cancer vaccine development. Given the involvement of DNA methylation in the development of lymphocytes, tumorigenicity and tumor progression, we aimed to analyze pre-vaccination DNA methylation profiles of peripheral blood mononuclear cells (PBMCs) from breast cancer subjects vaccinated with a novel peptide-based vaccine referred to as P10s-PADRE. This pilot study was performed to ...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
DiscussionThis trial attempts to investigate whether irinotecan treatment with a ketogenic diet for locally recurrent or metastatic breast cancer among women in northeast China can enhance the disease ’s sensitivity to chemotherapy and reduce target lesions.Trial registrationChinese Clinical Trial Registry, ID:ChiCTR1900024597. Registered on 18 July 2019. Protocol Version: 1.1, 24 February 2017.
Source: Trials - Category: Research Source Type: clinical trials
ConclusionTCHL was a tolerable regimen at a starting L dose of 750  mg PO daily when given concurrently with chemotherapy.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
We present our prospective study of chemoport implantation by external jugular vein cutdown technique. We studied 100 patients who underwent chemoport insertion over a span of 3  years for various solid and haematological malignancies via external jugular vein cutdown method. Outcomes such as type of disease, anaesthesia, choice of venous access, catheter tip position, length of the procedure, time to start chemotherapy and morbidity data were analysed. The Hundred /100 in travenous devices were implanted in 66% females and 33% males. Most common indication was breast cancer (64% of patients). A total of 80% of patien...
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
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