In This Issue

Arthritis&Rheumatology, Volume 72, Issue 4, April 2020.
Source: Arthritis and Rheumatology - Category: Rheumatology Tags: In This Issue Source Type: research

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Authors: Ceribelli A, Selmi C Abstract Genomic predisposition fails to fully explain the onset of complex diseases, which is well illustrated by the largely incomplete concordance among monozygotic twins. Epigenetic mechanisms, including DNA methylation, chromatin remodeling, and non-coding RNA, are the link between environmental stimuli and disease onset on a permissive genetic background in autoimmune and chronic inflammatory diseases. Autoimmune diseases now include almost 100 conditions and are estimated to cumulatively affect up to 5% of the world population with a healthcare expenditure superior to cancer wor...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/ Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study aimed to assess and compare...
Source: Pediatric Rheumatology - Category: Rheumatology Authors: Tags: Research article Source Type: research
Ankylosing spondylitis (AS) is characteristically male-predominant, and progressive spinal ankylosis affects male patients more severely; however, the hormonal effects in males with AS are poorly understood.
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Antibodies binding to cartilage proteins are present in the blood and synovial fluid of early rheumatoid arthritis patients. In order to develop animal models mimicking the human disease, we have characterized...
Source: Arthritis Research and Therapy - Category: Rheumatology Authors: Tags: Research article Source Type: research
Conclusions: Health-related quality of life was most prominently associated with bowel frequency during daytime, urgency of defecation, and blood in stool. Other symptoms associated for some health-related quality of life dimensions, and appear to vary between the sexes. PMID: 32442051 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Gastroenterology - Category: Gastroenterology Tags: Scand J Gastroenterol Source Type: research
CONCLUSIONS: While animal models have identified possible endocannabinoid pathways in arthritis, there is no clear evidence of benefit in humans or comparative efficacy with current treatments. At this stage, there is little evidence to support GPs prescribing cannabis-based medicinal products for arthritis. PMID: 32438375 [PubMed - in process]
Source: New Zealand Medical Journal - Category: General Medicine Tags: N Z Med J Source Type: research
Three drugs previously available only by prescription will now be available only over the counter: diclofenac sodium topical gel, 1% (Voltaren Arthritis Pain); olopatadine HCl ophthalmic solution/drops, 0.1% (Pataday Twice Daily Relief); and olopatadine HCl ophthalmic solution/drops, 0.2% (Pataday Once Daily Relief).
Source: AJN - Category: Nursing Tags: Drug Watch Source Type: research
Authors: Pablo AH, Breaud AR, Clarke W Abstract Immunosuppressant medications help suppress the immune system response through inhibition of various checkpoints in the regulatory biochemical pathway. This is useful in prevention of organ rejection in transplantation or in the treatment of autoimmune diseases such as lupus or rheumatoid arthritis. Quantification of immunosuppressive drugs in blood is needed clinically for optimization of treatment and to avoid toxicity or unwanted side effects. Here, we describe a quantitative method to determine the concentration of cyclosprine A, tacrolimus, sirolimus, and everoli...
Source: Current Protocols in Toxicology - Category: Toxicology Tags: Curr Protoc Toxicol Source Type: research
Dear Carol: My mom, age 79, has had steadily declining health for several years. Arthritis is a genetic problem in my family, so pain is an issue. Besides that, she has severe asthma, so her lungs show a lot of deterioration. The family has handled all of this but now her thinking is getting foggy. She’s resisted moving to assisted living even though we all know that this would probably be best. I work full time, so even though I live in her community, I can’t be with her all the time. I also have teenage kids so even checking on Mom every day is getting to be too much. I know that I’m just getting s...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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