Autotaxin (ATX) as a Marker for Breast Cancer

Condition:   Breast Cancer Interventions:   Diagnostic Test: Serum Autotaxin;   Radiation: chest x-ray;   Diagnostic Test: Breast ultrasound or mammography;   Diagnostic Test: Histopathological examination of breast mass specimens;   Radiation: Magnetic Resonance Imaging ( MRI) and Bone scan;   Diagnostic Test: Peripheral  haemogram;   Diagnostic Test: Renal and liver functions;   Diagnostic Test: Prothrombin time and concentration;   Diagnostic Test: Cancer Antigen 15-3 (CA15-3).;   Other: Full medical history;   Other: Full clinical examination Sponsor:   Assiut University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Jacinta E. Browne The aim of this work was to develop multimodal anthropomorphic breast phantoms suitable for evaluating the imaging performance of a recently-introduced Microwave Imaging (MWI) technique in comparison to the established diagnostic imaging modalities of Magnetic Resonance Imaging (MRI), Ultrasound (US), mammography and Computed Tomography (CT). MWI is an emerging technique with significant potential to supplement established imaging techniques to improve diagnostic confidence for breast cancer detection. To date, numerical simulations have been used to assess the different MWI scanning and image recon...
Source: Sensors - Category: Biotechnology Authors: Tags: Article Source Type: research
This article focuses on reviewing the background of microwave techniques for breast tumour detection. In particular, this study reviews the recent advancements in active microwave imaging, namely microwave tomography and radar-based techniques. The main objective of this paper is to provide researchers and physicians with an overview of the principles, techniques, and fundamental challenges associated with microwave imaging for breast cancer detection. Furthermore, this study aims to shed light on the fact that until today, there are very few commercially available and cost-effective microwave-based systems for breast canc...
Source: Sensors - Category: Biotechnology Authors: Tags: Review Source Type: research
Condition:   Breast Cancer Interventions:   Diagnostic Test: Serum Autotaxin;   Radiation: chest x-ray;   Diagnostic Test: Breast ultrasound or mammography;   Diagnostic Test: Histopathological examination of breast mass specimens;   Radiation: Magnetic Resonance Imaging ( MRI) and Bone scan;   Diagnostic Test: Peripheral  haemogram;   Diagnostic Test: Renal and liver functions;   Diagnostic Test: Prothrombin time and concentration;   Diagnostic Test: Cancer Antigen...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractPurposeTo develop a multiparametric [18F]FDG positron emission tomography/magnetic resonance imaging (PET/MRI) model for breast cancer diagnosis incorporating imaging biomarkers of breast tumors and contralateral healthy breast tissue.MethodsIn this prospective study and retrospective data analysis, 141 patients (mean 57  years) with an imaging abnormality detected on mammography and/or ultrasound (BI-RADS 4/5) underwent combined multiparametric [18F]FDG PET/MRI with PET/computed tomography and multiparametric MRI of the breast at 3  T. Images were evaluated and the following were recorded: for the tumor,...
Source: European Journal of Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
Conclusion: The texture analysis for breast DCE-MRI proposed in this study demonstrated potential utility in HER2 2+ status discrimination. Background Human epidermal growth factor receptor 2 (HER2) is an orphan tyrosine kinase receptor. It is reported that HER2 is overexpressed in 15–20% of breast cancers. Overexpression of HER2 in breast cancer correlates with shortened disease-free survival. Compared with HER2-negative patients, patients with HER2-positive breast cancers have a poor prognosis, a high probability of lymph node metastasis and a high risk of recurrence (1–3). However, previous studies h...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
Authors: D'Angelo A, Rinaldi P, Belli P, D'Amico R, Carlino G, Grippo C, Giuliani M, Orlandi A, Infante A, Manfredi R Abstract OBJECTIVE: We investigated the accuracy of Automated Breast Volume Scanner (ABVS) compared to handheld ultrasound (HHUS) for monitoring tumor response to neoadjuvant treatment (NAT) in breast cancer (BC). PATIENTS AND METHODS: All the patients submitted to biopsy in our Institution, from January 2017 to May 2017, proven invasive BC and eligible for NAT, were enrolled in this prospective study. The participants underwent ABVS, HHUS, dynamic contrast-enhanced Magnetic Resonance Imaging (D...
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
Publication date: November 2018Source: Academic Radiology, Volume 25, Issue 11Author(s): Rossella Rella, Paolo Belli, Michela Giuliani, Enida Bufi, Giorgio Carlino, Pierluigi Rinaldi, Riccardo ManfrediAutomated breast ultrasonography (ABUS) is a new imaging technology for automatic breast scanning through ultrasound. It was first developed to overcome the limitation of operator dependency and lack of standardization and reproducibility of handheld ultrasound. ABUS provides a three-dimensional representation of breast tissue and allows images reformatting in three planes, and the generated coronal plane has been suggested t...
Source: Academic Radiology - Category: Radiology Source Type: research
Conclusion: The results from this NMA indicate that the diagnostic value of the BSGI, MG + SMM, MRI and CE-MRI methods for BC were relatively higher in terms of sensitivity, specificity and accuracy.Cell Physiol Biochem 2018;46:2041 –2055
Source: Cellular Physiology and Biochemistry - Category: Cytology Source Type: research
Publication date: Available online 16 March 2018 Source:Academic Radiology Author(s): Rossella Rella, Paolo Belli, Michela Giuliani, Enida Bufi, Giorgio Carlino, Pierluigi Rinaldi, Riccardo Manfredi Automated breast ultrasonography (ABUS) is a new imaging technology for automatic breast scanning through ultrasound. It was first developed to overcome the limitation of operator dependency and lack of standardization and reproducibility of handheld ultrasound. ABUS provides a three-dimensional representation of breast tissue and allows images reformatting in three planes, and the generated coronal plane has been suggested to...
Source: Academic Radiology - Category: Radiology Source Type: research
ConclusionsThe study of radiomics in BC patients is a new and emerging translational research topic. Radiomics in BC is frequently done to potentially improve diagnosis and characterization, mostly using MRI. Substantial quality limitations were found; high-quality prospective and reproducible studies are needed to further potential application.
Source: Breast Cancer Research and Treatment - Category: Cancer & Oncology Source Type: research
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