Satisfactory long-term survival, functional and radiological outcomes of open-wedge high tibial osteotomy for managing knee osteoarthritis: Minimum 10-year follow-up study

Publication date: Available online 30 March 2020Source: Journal of Orthopaedic TranslationAuthor(s): Lawrence C.-M. Lau, Jason C.-H. Fan, Kwong-Yin Chung, Kin-Wing Cheung, Gene C.-W. Man, Yuk-Wah Hung, Carson K.-B. Kwok, Kevin K.-W. Ho, Kwok-Hing Chiu, Patrick S.-H. Yung
Source: Journal of Orthopaedic Translation - Category: Orthopaedics Source Type: research

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In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation. Lin28 as a Target for Nerve Regeneration Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitoch...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study aimed to investigate relationships of serum adiponectin, 25-hydroxyvitamin D (25(OH)D), interleukin (IL)-6, and physical performance in knee OA patients. A total of 175 knee OA patients and 52 healthy controls were recruited. Serum adiponectin, 25(OH)D, IL-6, biochemical markers, knee pain and functional scores, muscle strength, physical performance, metabolic parameters, and body composition were evaluated. Serum adiponectin levels were significantly higher in knee OA patients than that  in controls, while its serum levels were significantly decreased in obese patients, especially those with sarcopenia. Fu...
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research
Objective The aim of the study was to assess the effects of elastic taping on pain, physical function, range of motion, and muscle strength in patients with knee osteoarthritis. Design We searched the PubMed, the Cochrane Central Register of Controlled Trials, Web of Science, Physiotherapy Evidence Database, Scopus, EMBASE, OVID, CNKI, and WANFANG to identify relevant randomized controlled trials. The primary outcome measures were pain and physical function. The secondary outcome measures were range of motion and muscle strength. Results Eleven randomized controlled trials involving 490 patients with knee osteoarth...
Source: American Journal of Physical Medicine and Rehabilitation - Category: Rehabilitation Tags: Original Research Articles Source Type: research
Publication date: May–June 2020Source: Revista Española de Cirugía Ortopédica y Traumatología (English Edition), Volume 64, Issue 3Author(s): V. Machado, M. San-Julián
Source: Revista Espanola de Cirugia Ortopedica y Traumatologia - Category: Orthopaedics Source Type: research
AbstractPurposeKnee osteoarthritis (OA) is a musculoskeletal disorder that may have a heavy impact on the patients ’ quality of life. Intra-articular collagen injection may be a safe adjuvant. Recently, CHondroGrid (CG), a hydrolyzed (
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
This article reviews the biological characterization of WJ-MSCs in recent years, the ir advantages compared with other stem cells, and their application in the treatment of osteoarthritis in animal experiments and clinical trials.
Source: Human Cell - Category: Cytology Source Type: research
Publication date: Available online 15 May 2020Source: Journal of Taibah University Medical SciencesAuthor(s): Radwa F. Hammam, Ragia M. Kamel, Amira H. Draz, Amr A. Azzam, Shimaa T. Abu El Kasem
Source: Journal of Taibah University Medical Sciences - Category: Universities & Medical Training Source Type: research
FRIDAY, May 22, 2020 -- Use of biomechanical footwear is associated with an improvement in pain among patients with knee osteoarthritis at 24 weeks of follow-up, although the improvements are of uncertain clinical importance, according to a study...
Source: - Pharma News - Category: Pharmaceuticals Source Type: news
Pain is the most prominent symptom of osteoarthritis (OA) progression. However, the relationship between pain and OA progression remains largely unknown. Here we report osteoblast secret prostaglandin E2 (PGE2) during aberrant subchondral bone remodeling induces pain and OA progression in mice. Specific deletion of the major PGE2 producing enzyme cyclooxygenase 2 (COX2) in osteoblasts or PGE2 receptor EP4 in peripheral nerve markedly ameliorates OA symptoms. Mechanistically, PGE2 sensitizes dorsal root ganglia (DRG) neurons by modifying the voltage-gated sodium channel NaV1.8, evidenced by that genetically or pharmacologic...
Source: eLife - Category: Biomedical Science Tags: Human Biology and Medicine Neuroscience Source Type: research
Conclusions: In conclusion, in vitro findings suggest that the immunomodulatory effects of LMWF5A make it a viable candidate for treating cytokine storm and restoring homeostasis to the immune response in COVID-19. PMID: 32431755 [PubMed]
Source: Patient Safety in Surgery - Category: Surgery Authors: Tags: Patient Saf Surg Source Type: research
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