Double positivity for anti ‐N‐methyl‐d‐aspartate receptor and anti‐aquaporin‐4 antibodies in a patient presenting with hypersomnolence, personality change, and reduced spontaneity

ConclusionsAlthough her main symptoms were compatible with NMDARE, MRI findings were more compatible with NMOSD. Therefore, we interpreted her clinical and imaging features as a mixed phenotype of NMOSD and NMDARE. This case report provides additional evidence that double positivity for AQP4 ‐ab and NMDAR‐ab is associated with a mixed phenotype of NMOSD and NMDARE.

Source: Clinical and Experimental Neuroimmunology - March 31, 2020 Category: Neurology Authors: Motoi Yoshimura, Taira Uehara, Eizo Tanaka, Toshiki Okadome, Takahiro Yamaguchi, Yasuhiro Maeda, Noriko Isobe, Takuya Matsushita, Ryo Yamasaki, Jun ‐ichi Kira Tags: CASE REPORT Source Type: research