Twice-yearly inclisiran injections halve LDL-cholesterol levels

Nature Reviews Cardiology, Published online: 31 March 2020; doi:10.1038/s41569-020-0373-0The safety and durability of the LDL-cholesterol-lowering effects of inclisiran, a small interfering RNA that inhibits the synthesis of PCSK9 in the liver, have now been confirmed in three phase III clinical trials published in the New England Journal of Medicine.
Source: Nature Reviews Cardiology - Category: Cardiology Authors: Source Type: research

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Conclusion: This study demonstrated that physical activity and schooling are significantly associated with MetS, highlighting the importance of these factors for the control of this syndrome.
Source: Revista Brasileira de Epidemiologia - Category: Epidemiology Source Type: research
Contributors : Zachary Poss ; Steven Guard ; Jeremy Jacobsen ; William OldSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensCannabidiol (CBD) is an FDA approved drug for treatment of drug-intractable forms of pediatric epilepsy. While a unified mechanism of action has yet to emerge from numerous proposed molecular targets of CBD, preclinical studies reveal a pleiotropic pharmacology. Here, we report the application of temporally-resolved multi-omic profiling and biosensor screening to dissect the molecular mechanism of CBD in human neuroblastoma cells. CDB treatment led to a rise in cyt...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
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Source: The Journal of Lipid Research - Category: Lipidology Authors: Tags: Research Articles Source Type: research
Atherogenic LDL particles are physicochemically and metabolically heterogeneous. Can bioactive lipid cargo differentiate LDL subclasses, and thus potential atherogenicity? What is the effect of statin treatment? Obese hypertriglyceridemic hypercholesterolemic males [n = 12; lipoprotein (a)
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ConclusionsPCSK9 inhibitors reduce the incidence of myocardial infarction by 19% and stroke by 25%.
Source: Journal of Diabetes and Metabolic Disorders - Category: Endocrinology Source Type: research
Authors: Poznyak AV, Zhang D, Grechko AV, Wu WK, Orekhov AN Abstract Atherosclerosis is a major cause of disease-related mortality around the globe. The main characteristic of the disease is an accumulation of plaque on the arterial wall and subsequent erosion or rupture of some plaques. Atherosclerosis often leads to cardiovascular disease and such acute complications as myocardial infarction or ischaemic stroke due to thrombus formation. Most recent advances in atherosclerotic research state that the modifications of low- density lipoprotein (LDL) are one of the most significant stages in the disease initiation, ...
Source: Minerva Cardioangiologica - Category: Cardiology Tags: Minerva Cardioangiol Source Type: research
Conclusions: Interleukin-6 may be an indicator of inflammatory activity in psoriasis. Moreover, IL-6 may be related to lipid abnormalities in patients with this disease. PMID: 32467682 [PubMed]
Source: Advances in Dermatology and Allergology - Category: Dermatology Tags: Postepy Dermatol Alergol Source Type: research
Authors: Anagnostis P, Vaitsi K, Mintziori G, Goulis DG, Mikhailidis DP PMID: 32468870 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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