Cancers, Vol. 12, Pages 838: Immunomodulatory Molecules On Lung Cancer Stem Cells From Lymph Nodes Aspirates

We reported the higher frequency of MTCs and CSCs expressing the investigated immunomodulating molecules in metastatic LNs than in nonmetastatic. The expression of CD47 and PD-L1 was significantly higher on CSCs than on MTCs. Among the lymphocyte subpopulation in PB, we observed a higher frequency of PD-1+ CD8 T cells and Fas+ CD8 T cells in patients with confirmed metastases than in nonmetastatic. Next, we found that the percentage of FasL+ MTCs correlated with the frequency of Fas+ CD3 T cells in LNs aspirates and Fas+ CD8 T cells in PB. Finally, we found that patients with metastatic disease had a significantly higher FasL+/Fas+ MTCs ratio than patients with nonmetastatic disease. Both MTCs and CSCs express different immunomodulatory molecules on their surface. The frequency of FasL+ MTCs associates with altered distribution of Fas+ lymphocyte subpopulations in LNs and PB.

Source: Cancers - March 30, 2020 Category: Cancer & Oncology Authors: Agata Raniszewska Iwona Kwiecie ń Rafa ł Sokołowski El żbieta Rutkowska Joanna Domaga ła-Kulawik Tags: Article Source Type: research