Viruses, Vol. 12, Pages 380: Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women

Viruses, Vol. 12, Pages 380: Multiple HPV Infections and Viral Load Association in Persistent Cervical Lesions in Mexican Women Viruses doi: 10.3390/v12040380 Authors: Mariel A. Oyervides-Muñoz Antonio A. Pérez-Maya Celia N. Sánchez-Domínguez Anais Berlanga-Garza Mauro Antonio-Macedo Lezmes D. Valdéz-Chapa Ricardo M. Cerda-Flores Victor Trevino Hugo A. Barrera-Saldaña María L. Garza-Rodríguez Persistent high-risk human papillomavirus (HR-HPV) infections play a major role in the development of invasive cervical cancer (CC), and screening for such infections is in many countries the primary method of detecting and preventing CC. HPV typing can be used for triage and risk stratification of women with atypical squamous cells of undetermined significance (ASC-US)/low-grade cervical lesions (LSIL), though the current clinical practice in Mexico is to diagnose CC or its preceding conditions mainly via histology and HR-HPV detection. Additional information regarding these HPV infections, such as viral load and co-infecting agents, might also be useful for diagnosing, predicting, and evaluating the possible consequences of the infection and of its prevention by vaccination. The goal of this follow-up hospital case study was to determine if HPV types, multiple HPV infections, and viral loads were associated with infection persistence and the cervical lesion grade. A total of 294 cervical cytology samples drawn from patients with gynecological alteratio...
Source: Viruses - Category: Virology Authors: Tags: Article Source Type: research