Evaluation of fosphenytoin, levetiracetam, and propofol as treatments for nerve agent-induced seizures in pediatric and adult rats.

In this study, fosphenytoin and levetiracetam failed to terminate seizure activity when animals were treated 5 minutes after seizure onset. Propofol was effective, exhibiting high efficacy and potency for terminating seizure activity quickly in pediatric and adult animals, suggesting it may be an effective anticonvulsant for NA-induced seizures in pediatric populations. PMID: 32220603 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32220603?dopt=Abstract

Source: Neurotoxicology - March 23, 2020 Category: Neurology Authors: Dunn EN, Matson LM, Haines KM, Whitten KA, Lee-Stubbs RB, Berger KE, McCarren HS, Ardinger CE, Jackson Piercy CE, Miller-Smith SM, McDonough JH Tags: Neurotoxicology Source Type: research