Influence of the endocannabinoid system on the antidepressant activity of bupropion and moclobemide in the behavioural tests in mice.

CONCLUSION: The outcomes of the present study revealed that particularly activation or inhibition of the CB1 receptor function may augment the antidepressant activity of bupropion, whereas only inhibition of the CB1 receptor function manages to increase activity of moclobemide. Most probably, an interplay between CB receptor ligands and bupropion or moclobemide takes place at the cellular level. PMID: 32221841 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32221841?dopt=Abstract

Source: Pharmacological Reports - March 26, 2020 Category: Drugs & Pharmacology Authors: Poleszak E, Wośko S, Sławińska K, Wyska E, Szopa A, Świąder K, Wróbel A, Szponar J, Doboszewska U, Wlaź P, Wlaź A, Serefko A Tags: Pharmacol Rep Source Type: research