Methorexate and Knee Osteoarthritis

Conditions:   Pain Reduction;   Physical Function Improvement Interventions:   Drug: 25 mg/week oral methotrexate tablets;   Drug: 25mg/week oral placebo tablets Sponsor:   University of Alexandria Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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Recent literature suggests that adults do not necessarily develop osteoarthritis if they have an osteochondral lesion of the talus (OLT). The purpose of this study was to determine if children with OLT are at risk to develop any radiographic evidence of early joint degeneration despite treatment efforts. Fifty-six ankles were identified over 6 years with stable OLT that underwent operative treatment. Preoperatively, each lesion was classified according to Berndt-Hardy for radiographs, Hepple for MRI, and Ferkel and Sgaglione for computed tomography. Radiographs were also evaluated for physeal status, OLT characteristics (l...
Source: Journal of Pediatric Orthopaedics B - Category: Orthopaedics Tags: Leg & Foot Source Type: research
CONCLUSIONS: The novel semiautomated average cartilage thickness and echo-intensity assessment is efficient, systematic, and reliable between an expert and novice rater with minimal training. PMID: 32473587 [PubMed - as supplied by publisher]
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
CONCLUSIONS: Individuals with a history of ACLR who exhibited elevated levels of injury-related fear demonstrated slower VMRT. There were no relationships between self-reported knee function and VMRT. Future research should explore interventions to address injury-related fear and VMRT in individuals after ACLR. PMID: 32473583 [PubMed - as supplied by publisher]
Source: Journal of Sport Rehabilitation - Category: Sports Medicine Tags: J Sport Rehabil Source Type: research
MONDAY, June 1, 2020 -- Intra-articular dextrose prolotherapy (DPT) injections are a safe and effective treatment for knee osteoarthritis, according to a study published in the May/June issue of the Annals of Family Medicine. Regina Wing Shan Sit,...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
Discussion Myofascial pain is pain from muscle or fascia, and usually associated with myofascial trigger points which are “…a highly localized, hyperirritable spot in a palpable, taut band of skeletal muscle fibers.” Trigger points are common reasons people, especially adults, seek relief in primary care or pain clinic settings. Athletes may also complain of pain caused by them. They are treated in a variety of ways, none of which used as a single method is successful for all individuals. Muscle “…stretching, massage, ischemic compression, laser therapy, transcutaneous electrical nerve stimu...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Journal of Orthopaedic&Sports Physical Therapy,Volume 50, Issue 6, Page 309-318, June 2020.
Source: The Journal of Orthopaedic and Sports Physical Therapy - Category: Physiotherapy Authors: Source Type: research
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Source: Cell Cycle - Category: Cytology Authors: Source Type: research
The purpose of this study is to perform a systematic review and meta-analysis evaluating the effects of mesenchymal stem cells on cartilage regeneration and patient-reported pain and function.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Source Type: research
In conclusion, AK094629 knockdown attenuated the expression of IL‑1β‑regulated IL‑6 in the SMSCs of the temporomandibular joint by inhibiting MAP3K4. Therefore, AK094629 may be a potential novel therapeutic target for the treatment of temporomandibular joint osteoarthritis. PMID: 32468015 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
This study in...
Source: Journal of Experimental Orthopaedics - Category: Orthopaedics Authors: Tags: Research Paper Source Type: research
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