Cortical ischaemic patterns in term partial-prolonged hypoxic-ischaemic injury —the inter-arterial watershed demonstrated through atrophy, ulegyria and signal change on delayed MRI scans in children with cerebral palsy

AbstractThe inter-arterial watershed zone in neonates is a geographic area without discernible anatomic boundaries and difficult to demarcate and usually not featured in atlases. Schematics currently used to depict the areas are not based on any prior anatomic mapping, compared to adults.Magnetic resonance imaging (MRI) of neonates in the acute to subacute phase with suspected hypoxic-ischaemic injury (HII) can demonstrate signal abnormality and restricted diffusion in the cortical and subcortical parenchyma of the watershed regions.In the chronic stage of partial-prolonged hypoxic-ischaemic injury, atrophy and ulegyria can make the watershed zone more conspicuous as a region. Our aim is to use images extracted from a sizable medicolegal database (approximately 2000 cases), of delayed MRI scans in children with cerebral palsy, to demonstrate the watershed region.To achieve this, we have selected cases diagnosed on imaging as having sustained a term pattern of partial-prolonged HII affecting the hemispheric cortex, based on the presence of bilateral, symmetric atrophy with ulegyria. From these, we have identified those patients demonstrating injury along the whole watershed continuum as well as those demonstrating selective anterior or posterior watershed predominant injury for demonstration.Recognition of this zone is essential for diagnosing partial-prolonged hypoxic-ischaemic injury sustained in term neonates. The images presented in this pictorial review provide a template...
Source: Insights into Imaging - Category: Radiology Source Type: research

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CONCLUSION: Antenatal corticosteroid treatment in twins was associated with a beneficial effect on short-term neurologic outcomes only, without improvement in other short-term and medium-term outcomes. There was no difference related to chorionicity. PMID: 32459431 [PubMed - in process]
Source: Obstetrics and Gynecology - Category: OBGYN Authors: Tags: Obstet Gynecol Source Type: research
Fleeton, JRM, Sanders, RH, and Fornusek, C. Strength training to improve performance in athletes with cerebral palsy: A systematic review of current evidence. J Strength Cond Res 34(6): 1774–1789, 2020—Persons with cerebral palsy (CP) can partake in many different forms of organized sport including elite competition at state and international levels. There is limited evidence on how CP athletes should train to enhance performance. The purposes of this article were to conduct a systematic review of the current evidence on ambulatory individuals with CP for (a) strength and functional improvement through strength...
Source: Journal of Strength and Conditioning Research - Category: Sports Medicine Tags: Brief Review Source Type: research
Condition:   Cerebral Palsy Interventions:   Behavioral: HABIT-ILE;   Behavioral: Conventional intervention Sponsor:   Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cerebral Palsy Interventions:   Behavioral: HABIT-ILE with REAtouch®;   Behavioral: HABIT-ILE without REAtouch® Sponsor:   Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Child;   Cerebral Palsy;   Radiography;   Hip Dislocation;   Hip Displacement;   Prospective Studies Intervention:   Diagnostic Test: Radiographic examination with a Migration of> 40 % Sponsor:   Mette Røn Kristensen Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cerebral Palsy Interventions:   Behavioral: HABIT-ILE;   Behavioral: Conventional intervention Sponsor:   Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cerebral Palsy Interventions:   Behavioral: HABIT-ILE with REAtouch®;   Behavioral: HABIT-ILE without REAtouch® Sponsor:   Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Child;   Cerebral Palsy;   Radiography;   Hip Dislocation;   Hip Displacement;   Prospective Studies Intervention:   Diagnostic Test: Radiographic examination with a Migration of> 40 % Sponsor:   Mette Røn Kristensen Enrolling by invitation
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cerebral Palsy Interventions:   Behavioral: HABIT-ILE;   Behavioral: Conventional intervention Sponsor:   Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Cerebral Palsy Interventions:   Behavioral: HABIT-ILE with REAtouch®;   Behavioral: HABIT-ILE without REAtouch® Sponsor:   Université Catholique de Louvain Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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