Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosis.

Evaluation of cardiovascular autonomic dysfunction according to heart rate turbulence and variability in patients with relapsing remitting multiple sclerosis. Turk J Med Sci. 2020 Mar 28;: Authors: Gökaslan S, Demirbaş H, Özer Gökaslan Ç Abstract BACKGROUND/AIM: Multiple sclerosis (MS) is an autoimmune disease characterized by neurodegeneration or demyelination, and the relapsing?remitting phase of MS is characterized by acute exacerbation of disease activity. The most commonly used non-invasive approach to assess autonomic function is the determination of heart rate turbulence (HRT) and heart rate variability (HRV). The aim of this study was to evaluate the presence of cardiovascular autonomic dysfunction using HRT and HRV parameters determined via 24-hour Holter ECG monitoring in patients with relapsing-remitting MS without known heart disease. MATERIALS AND METHODS: The study included 26 patients diagnosed with relapsing?remitting MS and 22 age- and sex-matched healthy controls. HRT and HRV parameters were analyzed via 24-hour Holter ECG monitoring. Magnetic resonance imaging findings were re-evaluated to identify any demyelinating lesions in the brain stem. RESULTS: The HRV parameters of SDNNI (mean of the standard deviations of all normal sinus RR intervals in all 5-minute segments), rMSSD (root-mean-square successive difference), and sNN50 (percentage of successive normal sinus RR intervals> 50 ms) were significantl...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research

Related Links:

CONCLUSIONS: These results indicate that the CAIDE dementia risk score is associated with cortical thickness and cognitive function at midlife in a low-risk population. These data provide insight into subclinical structural and functional changes occurring during midlife associated with future risk for the development of dementia. PMID: 32467426 [PubMed - as supplied by publisher]
Source: Alzheimer Disease and Associated Disorders - Category: Psychiatry Tags: Alzheimer Dis Assoc Disord Source Type: research
Authors: Delibasis Κ, Aronis C, Fanariotis M, Maglogiannis I Abstract Magnetic resonance imaging (MRI) is an established clinical technique that measures diffusion-weighted signals, applied primarily in brain studies. Diffusion tensor imaging (DTI) is a technique that uses the diffusion-weighted signals to obtain information about tissue connectivity, which recently started to become established in clinical use. The extraction of tracts (tractography) is an issue under active research. In this work we present an algorithm for recovering tracts, based on Dijkstra's minimum-cost path. A novel cost definition al...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In this study, we used three supervised machine learning (ML) techniques to differentiate MCI converters (MCIc) from MCI non-converters (MCInc) and predict their conversion rates from baseline MRI data (cortical thickness (CTH) and hippocampal volume (HCV)). A total of 803 participants from the ADNI cohort were included in this study (188 AD, 107 MCIc, 257 MCInc and 156 healthy controls (HC)). We studied the classification abilities of three different WEKA classifiers (support vector machine (SVM), decision trees (J48) and Naive Bayes (NB)). We built six different classification models, three models based on CTH and three ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In this study, five machine learning algorithms and twelve types of molecular fingerprints were employed to generate QSAR discriminant models for mitochondrial toxicity. A threshold moving method was adopted to resolve the imbalance issue in the training data. Consensus of the models by an averaging probability strategy improved prediction performance. The best model has correct classification rates of 81.8% and 88.3% in ten-fold cross validation and external validation, respectively. Substructures such as phenol, carboxylic acid, nitro and arylchloride were found informative through analysis of information gain and freque...
Source: Chemosphere - Category: Chemistry Authors: Tags: Chemosphere Source Type: research
HEART attack symptoms include difficulty breathing, severe chest pain, and feeling sick. But, you could also be at risk of a deadly myocardial infarction and heart disease if your toes turn a strange colour. This is the skin condition you should avoid.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This study aimed to investigate how a unilateral high-grade tear caused overdistension of LAM and whether tear positions affect the degree of distension. Methods A total of 209 women were screened by translabial ultrasonography. Then, 18 nulliparous women with an intact LAM and 26 postpartum women with unilateral levator ani defects were recruited. The anteroposterior diameter (AP), coronal diameter (LR), and hiatal area (HA) of the minimum levator hiatus were recorded and compared for assessing the distensibility. All 44 subjects underwent magnetic resonance imaging for the diagnosis of levator ani defect and detection...
Source: Female Pelvic Medicine and Reconstructive Surgery - Category: OBGYN Tags: Original Articles Source Type: research
Publication date: Available online 29 May 2020Source: Multiple Sclerosis and Related DisordersAuthor(s): Helena Beatriz Ferreira, Bruna Neves, Inês M. Guerra, Ana Moreira, Tânia Melo, Artur Paiva, M. Rosário Domingues
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Did you know diabetes affects your mental health? From depression to relationship problems or mood swings, too much or too little glucose (sugar) circulating in the blood can trigger behavior and thought patterns that may seem unrelated to how much insulin is released by your pancreas. Out of control glucose levels influence how you feel and make decisions, your beliefs and, yes, your attitude, a very necessary component of your overall care.  The U.S. Centers for Disease Control and Prevention (CDC) states less than half the number of people with diabetes who have depression get treated, which leads to worsening stat...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Mental Health and Wellness Comorbidities Diabetes Drug Interactions Nutrition Source Type: blogs
Abstract Cerebral venous thrombosis (CVT) is an uncommon cause of stroke that mainly affects young adults with known risk factors of prothrombotic conditions, pregnancy, infection, malignancy, and drugs. Dutasteride is a 5α-reductase inhibitor that is used for benign prostate hypertrophy and androgenetic alopecia. To date, CVT caused by dutasteride use has not been reported. A 25-year-old male presented with headache and diplopia. He had taken 0.5 mg of dutasteride every other day for 9 months to treat alopecia. A headache developed 7 months after he started taking medication, and horizontal diplopia occurre...
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
We report three cases of focal anterior interosseous fascicular involvement in the median nerve trunk presenting as AIN palsy. Our report emphasizes the unique ultrasonographic and magnetic resonance imaging (MRI) features of swelling, hourglass-like constriction and torsion, and entwinement of the nerve fascicle of the dorsal region of the median nerve, which were confirmed surgically. On MRI, all patients showed denervation changes in the AIN territory, as well as in the median nerve territory, without compressing structures. PMID: 32469179 [PubMed - in process]
Source: Yonsei Medical Journal - Category: Universities & Medical Training Authors: Tags: Yonsei Med J Source Type: research
More News: Autoimmune Disease | Brain | Cardiology | Cardiovascular | General Medicine | Heart | Heart Disease | MRI Scan | Multiple Sclerosis | Neurology | Reflex Sympathetic Dystrophy | Study | Turkey Health