The innate immune cells in cirrhosis

Cirrhosis is a multi-systemic disease where inflammatory responses originating from advanced liver disease and its sequelae affect distant compartments. Patients with cirrhosis are susceptible to develop bacterial infections, which may precipitate acute decompensation (AD) and acute-on-chronic liver failure (ACLF), associated with a high short-term mortality. Innate immune cells are essential as first line of defence against pathogens due to their various rapid antibacterial activities such as the production of reactive oxygen species (ROS) via NADPH oxidases (NOX), degranulation, phagocytosis, and formation of extracellular chromatin traps.
Source: Journal of Hepatology - Category: Gastroenterology Authors: Tags: Review Source Type: research