Adenocarcinoma of the uterine cervix shows impaired recruitment of cDC1 and CD8+ T cells and elevated β-Catenin activation compared to squamous cell carcinoma.

CONCLUSIONS: Our data have identified an opportunity for the investigation of potentially novel therapeutic interventions in AC of the cervix, i.e. β-catenin inhibition and cDC1 mobilization.
PMID: 32220890 [PubMed - as supplied by publisher]

Source: Clinical Cancer Research - March 26, 2020 Category: Cancer & Oncology Authors: Rotman J, Heeren AM, Gassama AA, Lougheed SM, Pocorni N, Stam AGM, Bleeker MCG, Zijlmans HJMAA, Mom CH, Kenter GG, Jordanova ES, de Gruijl TD Tags: Clin Cancer Res Source Type: research