Targeting pulmonary capillary permeability to reduce lung congestion in heart failure: a randomized, controlled pilot trial
ConclusionIn this pilot trial, GSK2798745 was found to be safe and well ‐tolerated, with a trend toward improved gas transfer. Further investigation is warranted in larger studies to determine whether treatment with TRPV4 antagonists or alternative treatments targeting capillary permeability might be effective to improve lung congestion, pulmonary gas transfer and cli nical status in patients with acute or chronic
HF.
Source: European Journal of Heart Failure - Category: Cardiology Authors: Glenn M. Stewart,
Bruce D. Johnson,
Dennis L. Sprecher,
Yogesh N.V. Reddy,
Masaru Obokata,
Steven Goldsmith,
Brad Bart,
Anna Oughton,
Christina Fillmore,
David J. Behm,
Barry A. Borlaug Tags: Short Report Source Type: research
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