Lung Cancer Cells Derived Circulating miR-21 Promotes Differentiation of Monocytes into Osteoclasts
Purpose of review There are several first-line systemic therapy options for patients with newly diagnosed stage IV non-small-cell lung cancer. Targeted therapy with tyrosine kinase inhibitors provide a good first option for some. Unfortunately, most patients do not have an alteration for which there is an available tyrosine kinase inhibitor. For these patients there are immunotherapy and chemoimmunotherapy options; however, there is debate about how to choose amongst these treatments for a given individual. This review attempts to simplify this decision-making process. Recent findings The data on first-line immunother...
Purpose of review Patients with lung cancer are particularly vulnerable to lung injury associated with immune checkpoint inhibition and often present with more frequent and more severe manifestations of lung disease compared to patients with other tumor types. The present review explores the reasons for increased susceptibility to immune checkpoint-related lung injury among this group of patients and focuses on the current knowledge of the clinical and radiologic manifestations of lung injury associated with immune checkpoint blockade and current treatment strategies. Recent findings Recent investigations have shown t...
Purpose of review The essential role of endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) in lung cancer diagnosis and staging is now well established. With a growing body of evidence seen over the last decade, the objective of this article was to review the newest findings, provide evidence-based guidance to clinicians and identify areas for future research related to EBUS-TBNA and staging in lung cancer. Recent findings Recent literature regarding EBUS-TBNA for lung cancer staging was reviewed, with a focus on evidence published subsequent to the 2016 guideline on technical aspects of EBUS...
Conditions: Carcinoma; Lung Cancer; NSCLC; Lung Neoplasms Intervention: Diagnostic Test: Breath test Sponsors: Peking University People's Hospital; Beijing Haidian Hospital; Aerospace 731 Hospital; Beijing Breatha Biological Technology Co., Ltd, Beijing Not yet recruiting
Condition: Lung Cancer Intervention: Sponsor: Collège des Pneumologues des Hôpitaux Généraux Recruiting
Condition: Small Cell Lung Cancer Limited Stage Intervention: Drug: Toripalimab Sponsors: Sun Yat-sen University; The First Affiliated Hospital of Guangzhou Medical University; Guangzhou Panyu Central Hospital Not yet recruiting
This study provides insight into the epidemiological characteristics of spinal metastasis and health care service utilization in spinal metastasis patients in China. ABBREVIATIONS: ICD-10: International Classification of Disease, Tenth Revision; VAS: Visual Analogue Scale; KPS: Karnofsky Performance Status; SINS: Spinal Instability Neoplastic Score; SOSG: Spine Oncology Study Group; MRI: Magnetic Resonance Imaging; CT: Computed Tomography; ECT: Emission Computed Tomography. PMID: 32497469 [PubMed - as supplied by publisher]
CONCLUSIONS: In our study, GBP1 was firstly identified as a novel oncogene in NSCLC. Furthermore, it could promote NSCLC development and paclitaxel resistance by inducing Wnt/β-catenin signaling pathway. PMID: 32495881 [PubMed - in process]
CONCLUSIONS: This study revealed that the downregulation of lncRNA NORAD could slow down the progression of NSCLC by regulating CXCR4 and RhoA/ROCK signaling pathway. PMID: 32495879 [PubMed - in process]
Publication date: Available online 4 June 2020Source: Clinica Chimica ActaAuthor(s): Ruiling Zu, Sisi Yu, Guishu Yang, Yiman Ge, Dongsheng Wang, Li Zhang, Xiaoyu Song, Yao Deng, Qiao He, Kaijiong Zhang, Jian Huang, Huaichao Luo