Comment on: “Exploring the best treatment options for BRAF-mutant metastatic colon cancer”

British Journal of Cancer, Published online: 31 March 2020; doi:10.1038/s41416-020-0819-5Comment on: “Exploring the best treatment options for BRAF-mutant metastatic colon cancer”
Source: British Journal of Cancer - Category: Cancer & Oncology Authors: Source Type: research

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Conditions:   Cancer of Breast;   Cancer Colon Interventions:   Dietary Supplement: ONS Pre-op + ONS Post-op;   Dietary Supplement: ONS Pre-op + ONS Post-op + ONS Post-op 3 months;   Dietary Supplement: Usual intake Pre-op + ONS Post-op Sponsors:   International Medical University;   Kotra Pharma (M) Sdn Bhd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article reviews alternative colorectal cancer (CRC) screening tests, including flexible sigmoidoscopy (FS), computed tomography (CT) colonography, and colon capsule endoscopy. FS has abundant and convincing evidence supporting its use for CRC screening and is a commonly used CRC test worldwide. CT colonography has demonstrated convincing results for CRC screening, but concerns regarding cost, accuracy for flat or sessile neoplasia, reproducibility, extracolonic findings, and lack of coverage have limited its use and development. Colon capsule endoscopy has demonstrated encouraging results for polyp detection in averag...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Gastrointest Endosc Clin N Am Source Type: research
Abstract Early onset colorectal cancer (EOCRC) refers to colorectal cancer (CRC) in individuals under age 50. Although the incidence and mortality due to later onset CRC (≥50 years) has been declining over several decades, both are increasing in those under 50. EOCRC is more likely to occur in the distal colon and rectum. There are some unique pathologic and genetic features to these tumors; they are not usually associated with a germline mutation in a gene that predisposes to cancer, and at least some may have a distinct pathogenesis. Initiating CRC screening at an earlier age (40-45 years of age) would p...
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Gastrointest Endosc Clin N Am Source Type: research
This study aims to identify preoperative risk factors for non-reversal of intended temporary stomas created during acute resection of left-sided obstructive colon cancer (LSOCC) with primary anastomosis.MethodsAll patients who underwent emergency resection for LSOCC with primary anastomosis and a defunctioning stoma between 2009 and 2016 were selected from the Dutch ColoRectal Audit, and additional data were collected in the local centers. Multivariable analysis was performed to identify independent preoperative factors for non-closure of the stoma.ResultsA total of 155 patients underwent acute resection for LSOCC with pri...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Conditions:   Cancer of Breast;   Cancer Colon Interventions:   Dietary Supplement: ONS Pre-op + ONS Post-op;   Dietary Supplement: ONS Pre-op + ONS Post-op + ONS Post-op 3 months;   Dietary Supplement: Usual intake Pre-op + ONS Post-op Sponsors:   International Medical University;   Kotra Pharma (M) Sdn Bhd Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Colorectal carcinoma (CRC) is the leading cause of cancer-related deaths worldwide. Despite advances in prevention and treatment modalities for CRC, rapidly developing resistance to chemotherapy limits its effectiveness. For that reason, it is important to better understand the mechanisms that undergird the process of chemoresistance to enable design of novel anticancer agents specifically targeting malignant properties of cancer cells. Over recent decades, bioactive sphingolipid species have come under the spotlight for their recognized role in cancer development and progression, and the evidence has surfaced to sup...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Source: OncoTargets and Therapy - Category: Cancer & Oncology Tags: OncoTargets and Therapy Source Type: research
In this study, we investigated the antitumor activities of H2Mab-19 in pancreatic cancer xenograft models. We selected MIA PaCa-2, a pancreatic cancer cell line which expresses HER2. H2Mab-19 showed high binding affinity (KD: 1.2 × 10-8 M) against MIA PaCa-2 cells. Furthermore, H2Mab-19 significantly reduced tumor development in a MIA PaCa-2 xenograft model. These results suggest that treatment with H2Mab-19 may be a useful therapy for patients with HER2-expressing pancreatic cancers. PMID: 32423281 [PubMed - as supplied by publisher]
Source: Monoclonal Antibodies in Immunodiagnosis and Immunotherapy - Category: Microbiology Tags: Monoclon Antib Immunodiagn Immunother Source Type: research
Diabetes has been associated with increased risk of cancer, including breast cancer and colorectal cancer. Metformin, an oral hypoglycemic drug, but not other anti-diabetic drugs, has been associated with reduced risk of breast and of colon cancers in some, but not in other, studies.
Source: Diabetes Research and Clinical Practice - Category: Endocrinology Authors: Source Type: research
In conclusion, LPPC enhanced the antitumor activity and cellular uptake of BP, and the BP/LPPC complex induced cell cycle arrest and apoptosis, thereby causing death. These findings suggest the putative use of BP/LPPC as an adjuvant cytotoxic agent for colorectal cancer.
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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