Distribution of Parkinson ’s disease associated RAB39B in mouse brain tissue

In this study we investigated the expression and localization of RAB39...
Source: Molecular Brain - Category: Neuroscience Authors: Tags: Short report Source Type: research

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Publication date: September 2020Source: Neurochemistry International, Volume 138Author(s): Cui Liu, Yan Xue, Mei-Fang Liu, Ying Wang, Lei Chen
Source: Neurochemistry International - Category: Neuroscience Source Type: research
Authors: Wang S, Guo P, Feng M, Qian M, Shen X, Wang G PMID: 32447268 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
There is a considerable overlap between Parkinson's Disease Dementia (PDD) and Dementia with Lewy Bodies (DLB). They present a challenge therapeutically, with regard to morbidity and mortality risk. In particular, symptoms of psychosis in these conditions augur a considerably increased burden.To date, there has been a myriad of prospective, retrospective and case studies examining the use of neuroleptics in the treatment of psychotic symptoms in PDD/DLB. Clozapine has the most robust evidence base however its use is limited by agranulocytosis risk and the associated need for frequent blood count monitoring.
Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Tags: Review article Source Type: research
There was an interview on BBC Breakfast last week with a detection dog, or, strictly, with someone fromMedical Detection Dogs, accompanied by a detection dog.  Dogs have been used to " sniff out " malaria and Parkinson's, and there are investigations into whether they can be trained to detect COVID-19.There are details of that trial, which involves the University of Durham, the London School of Hygiene and Tropical Medicine, and Medical Detection Dogs,on this Government webpage. So what is in the literature?   A PubMed search for detection dog finds some papers, but also a lot about detec...
Source: Browsing - Category: Databases & Libraries Source Type: blogs
PARKINSON'S DISEASE is a progressive neurological condition which tends to affect a person's movement. A tremor is one of the main symptoms associated with the condition. But not all the symptoms of Parkinson's disease are motor - one sign may appear in a person's voice.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 22 May 2020Source: Trends in Cognitive SciencesAuthor(s): Carolyn Parkinson, Meng Du
Source: Trends in Cognitive Sciences - Category: Psychiatry & Psychology Source Type: research
This study evaluated the efficacy of 50  mg/kg purified anacardic acids (AAs), isolated from cashew nut shell liquid, on multiple steps of oxidative stress and inflammation induced by rotenone in thesubstantia nigra (SN) and striatum. Adult mice were divided into four groups: Control, rotenone, AAs  + rotenone, and AAs alone. Lipoperoxidation, nitric oxide (NO) levels, and reduced glutathione (GSH)/oxidized gluthatione (GSSG) ratio were evaluated. NF‐kB‐p65, pro‐IL‐1β, cleaved IL‐1β, metalloproteinase‐9, Tissue Inhibitory Factor‐1 (TIMP‐1), tyrosine hydroxylase (TH), and glial...
Source: IUBMB Life - Category: Research Authors: Tags: RESEARCH COMMUNICATION Source Type: research
Molecules, Vol. 25, Pages 2444: Anti-aggregation Effects of Phenolic Compounds on α-synuclein Molecules doi: 10.3390/molecules25102444 Authors: Kenjiro Ono Mayumi Tsuji Tritia R. Yamasaki Giulio M. Pasinetti The aggregation and deposition of α-synuclein (αS) are major pathologic features of Parkinson’s disease, dementia with Lewy bodies, and other α-synucleinopathies. The propagation of αS pathology in the brain plays a key role in the onset and progression of clinical phenotypes. Thus, there is increasing interest in developing strategies that attenuate...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Publication date: 2020Source: International Review of Neurobiology, Volume 152Author(s): Daniel J. van Wamelen, Yi-Min Wan, K. Ray Chaudhuri, Peter Jenner
Source: International Review of Neurobiology - Category: Neuroscience Source Type: research
PARKINSON's disease is a neurological brain condition that worsens over time. Best spotted sooner rather than later, what's the early sign you need to look out for when you go to the loo?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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