Effect of ABT-335 (fenofibric acid) on meal-induced oxidative stress in patients with metabolic syndrome

Abstract: Objective: Examine the effect of ABT-335 (fenofibric acid) on postprandial lipemia and susceptibility of plasma lipoproteins to Cu++-mediated oxidation in patients with metabolic syndrome.Methods and results: This is a randomized double-blind, placebo-controlled study with cross-over and includes a 4-week wash-out period between the two treatment periods. At the end of each 8-week treatment period, subjects were challenged with a standardized mixed meal followed by blood collection over the ensuing 6 h. Plasma lipoproteins were isolated by a combination of ultracentrifugation and FPLC for the continuous monitoring of conjugated dienes formation as an assessment of oxidative susceptibility. Fasting plasma TG was reduced by 20% (p 
Source: Atherosclerosis - Category: Cardiology Authors: Tags: Clinical & Population Research - Epidemiology, Biomarkers, Nutrition Source Type: research