GSE140190 Abrogation of esophageal carcinoma development by miR-31 genetic knockout

Contributors : Louise Y Fong ; Cristian Taccioli ; Alexey Palamarchuk ; Guidantonio M Tagliazucchi ; Ruiyan Jing ; Karl J Smalley ; Sili Fan ; Joseph Altemus ; Oliver Fiehn ; Kay Huebner ; John L Farber ; Carlo M CroceSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusTranscriptomics analyses in these Zn-deficient rats revealed the molecular basis of ESCC abrogation by miR-31 knockout: Egln3, a negative regulator of NF-FB, was shown to be a direct miR-31 target; miR-31 inhibition/deletion resulted in suppression of miR-31-associated-EGLN3-NF-KB controlled inflammatory pathways.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research