Delaying surgery by more than 10  weeks after long-course neoadjuvant radiotherapy in locally advanced rectal cancer patients improves pathologic complete response

AbstractBackgroundWe currently do not know the optimal time interval between the end of chemoradiotherapy and surgery. Longer intervals have been associated with a higher pathological response rate, worse pathological outcomes and more morbidity. The aim of this study was to evaluate the effect and safety of the current trend of increasing time interval between the end of chemoradiotherapy and surgery (
Source: Updates in Surgery - Category: Surgery Source Type: research

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ConclusionRadiomics of pretreatment MRIs can predict pCR, TRG, and NAR score in patients with LARC undergoing neoadjuvant treatment and TME with moderate accuracy despite extremely heterogenous image data. Both the tumor and MC contain important prognostic information.Key Points• Machine learning of rectal cancer on images from the pretreatment MRI can predict important patient outcomes with moderate accuracy.• The tumor and the tissue around it both contain important prognostic information.
Source: European Radiology - Category: Radiology Source Type: research
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Locally Advanced Rectal Cancer Interventions:   Drug: PD-1 antibody;   Drug: Capecitabine;   Drug: Irinotecan;   Radiation: Neoadjuvant Radiotherapy Sponsor:   Fudan University Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This article will make a further study on this point. Methods: We collected perioperative clinical data from 382 patients with rectal cancer who underwent surgery from September 2015 to May 2017. After 1 month of follow-up, relevant risk factor data were collected and analyzed. Results: Data analysis showed that the incidence of AL was 14.65%. In single factor analysis, patients with high score of NRS-2002, high score of PG-SGA, diabetes, perioperative blood transfusion, postoperative diarrhea, later tumor stage, high score of ASA, low postoperative albumin, and rectal cancer patients with tumor close to the anus...
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
More News: Cancer | Cancer & Oncology | Neoadjuvant Chemotherapy Therapy | Neoadjuvant Therapy | Rectal Cancers | Study | Surgery