Negative Regulation of Osteoclast Commitment by Intracellular Protein Phosphatase Magnesium ‐Dependent 1A

ConclusionThe loss ofPPM1A function in osteoclast precursors driven by inflammatory signals contributes to osteoclast lineage commitment and differentiation by elevating RANK expression, reflecting a potential role of PPM1A in dynamic bone metabolism in axial SpA.

Source: Arthritis and Rheumatology - March 30, 2020 Category: Rheumatology Authors: Oh Chan Kwon, Bongkun Choi, Eun ‐Jin Lee, Ji‐Eun Park, Eun‐Ju Lee, Eun‐Young Kim, Sang‐Min Kim, Min‐Kyung Shin, Tae‐Hwan Kim, Seokchan Hong, Chang‐Keun Lee, Bin Yoo, William H. Robinson, Yong‐Gil Kim, Eun‐Ju Chang Tags: Original Article Source Type: research