Role of Systemic Lupus Erythematosus Risk Variants With Opposing Functional Effects as a Driver of Hypomorphic Expression of TNIP1 and Other Genes Within a Three ‐Dimensional Chromatin Network

ConclusionHypomorphicTNIP1 expression results from the combined concordant and opposing effects of multiple risk variants carried on theTNIP1 risk haplotype, with the strongest regulatory effect in B lymphoid lineage cells. Furthermore, theTNIP1 risk haplotype effect extends to neighboring genes within a shared chromatin network.

Source: Arthritis and Rheumatology - March 30, 2020 Category: Rheumatology Authors: Satish Pasula, Kandice L. Tessneer, Yao Fu, Jaanam Gopalakrishnan, Richard C. Pelikan, Jennifer A. Kelly, Graham B. Wiley, Mandi M. Wiley, Patrick M. Gaffney Tags: Original Article Source Type: research