The Obesity Paradox: Obese Patients with HFpEF and HFrEF are Equally at Higher Risk of Readmission

Publication date: March–April 2020Source: Heart &Lung, Volume 49, Issue 2Author(s): Zachary Cox, Pikki Lai, Connie Lewis, JoAnn Lindenfeld
Source: Heart and Lung: The Journal of Acute and Critical Care - Category: Respiratory Medicine Source Type: research

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ConclusionsUnlike [18F]FDG, [18F]BODIPY 1 showed prominent accumulation in BAT under both inactive and stimulated status. [18F]BODIPY 1 may serve as a valuable BAT PET agent to possibly assess BAT mitochondria density, thus BAT thermogenic capacity after further evaluation.
Source: Molecular Imaging and Biology - Category: Molecular Biology Source Type: research
Authors: Abdelhamid BM, Khaled D, Mansour M, Hassan MM Abstract BACKGROUND: Pain control in the morbidly obese has presented as an anesthetic challenge. The aim of this study is to assess the analgesic efficacy of ultrasound guided bilateral erector spinae block compared to bilateral subcostal transversus abdominis plane block. METHODS: Prospective randomized, double-blinded controlled study was conducted at Kasr Alainy Hospital on 66 patients scheduled for laparoscopic sleeve gastrectomy. Patients were randomly allocated into three groups and received general anesthesia: bilateral erector spinae block at the l...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
ConclusionDespite the advances made in bariatric surgery, the criteria determining suitability of patients for bariatric surgery in most parts of the world are still based on a consensus agreed upon in the USA in 1991. There is a need to formulate some new consensus and guidelines that would allow for a significant expansion of the pool of patients that can be offered these procedures.
Source: Current Obesity Reports - Category: Eating Disorders & Weight Management Source Type: research
Publication date: Available online 25 May 2020Source: Journal of Psychiatric ResearchAuthor(s): Ruth Bartelli Grigolon, Elisa Brietzke, Alisson Paulino Trevizol, Roger S. McIntyre, Rodrigo B. Mansur
Source: Journal of Psychiatric Research - Category: Psychiatry Source Type: research
Publication date: Available online 25 May 2020Source: Seminars in Cell &Developmental BiologyAuthor(s): Staci E. Engle, Ruchi Bansal, Patrick J. Antonellis, Nicolas F. Berbari
Source: Seminars in Cell and Developmental Biology - Category: Cytology Source Type: research
In today's open access paper, the authors demonstrate a form of vaccination against a surface marker that appears on a subset of senescent T cells that reside in fat tissue, thus directing the rest of the immune system to attack and destroy these cells. There is good evidence for excess fat tissue to result in an increased burden of senescent cells, which disrupt metabolism via the generation of inflammatory signals. A novel branch of medicine is under construction, based on senolytic therapies capable of selectively destroying senescent cells in aged tissues. The growing numbers of senescent cells in older people (and eve...
Source: Fight Aging! - Category: Research Authors: Tags: Medicine, Biotech, Research Source Type: blogs
This study aimed at testing the effect of vitamin D supplements on urinary megalin levels in diabetic nephropathy (DN) patients with vitamin D hypovitaminosis. METHODS: A sample of 63 participants with vitamin D deficiency with diabetic nephropathy (DN) were enrolled in the pre-post study; urinary megalin levels with various clinical parameters and serum levels of vitamin D3 were measured and compared to the baseline at 3- and 6-month intervals. RESULTS: Interestingly, a supplementation related increase in serum vitamin D3 levels at 3- and 6- month interventions affected a constellation of ameliorations in the DN p...
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Drugs & Pharmacology Tags: Endocr Metab Immune Disord Drug Targets Source Type: research
Publication date: 1 August 2020Source: Physiology &Behavior, Volume 222Author(s): Michael C. Farruggia, Maria J. van Kooten, Emily E. Perszyk, Mary V. Burke, Dustin Scheinost, R. Todd Constable, Dana M. Small
Source: Physiology and Behavior - Category: Physiology Source Type: research
Abstract Diabetes has been associated with metabolic disorder, insulin resistance and neuroinflammation. However, the pathogenesis for HFD-induced injury of central nervous system (CNS) is still unclear. Tripartite Motif Containing 13 (TRIM13), also known as RFP2, is a member of TRIM proteins, and is associated with multiple cellular processes, such as apoptosis, survival and inflammation. However, the effects of TRIM13 on brain injury, especially the HFD-induced CNS damage, have not been investigated. To address this issue, the TRIM13flox/flox (fl/fl) mice were produced and then crossed them with Nestin-Cre mice ...
Source: Biochemical and Biophysical Research communications - Category: Biochemistry Authors: Tags: Biochem Biophys Res Commun Source Type: research
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