Optimizing Statin Tratment

Condition:   Diabetes Intervention:   Sponsor:   University Hospital, Montpellier Active, not recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials

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This study assesses the current practices of physicians in Lebanon routinely involved in ischemic stroke (IS) management. We conducted a prospective observational study of patients hospitalized at 8 different Lebanese hospitals in the period August 1, 2015 to July 31, 2016, with a diagnosis of acute stroke. Baseline characteristics and data on diagnostic studies, as well as treatments received during hospitalization and at discharge, were collected and analyzed. Two hundred and three strokes/transient ischemic attacks (TIAs) were recorded but only 173 patients (85%) with ischemic events were included in the study. The pati...
Source: Functional Neurology - Category: Neurology Tags: Funct Neurol Source Type: research
In the absence of an effective drug or vaccine against novel severe acute respiratory syndrome corona virus (SARS-Cov-2) till date, “repurposing approach” of old pharmaceuticals has been applied to combat against 2019-coronavirus disease (COVID-19). Hydroxychloroquine, anti-retrovirals, type-1 angiotesin receptor blockers, statin, vitamin D, melatonin etc are being tried with questionable benefits [1]. While there are intens ive debates regarding safety of different classes of antidiabetics at the advent of COVID-19 [2,3], multiple ongoing studies are evaluating the adjuvant role of various antidiaetics like di...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Letter to the Editor Source Type: research
People with diabetes mellitus (DM), especially those who are older, are at higher risk for premature morbidity and mortality related to atherosclerotic cardiovascular disease (ASCVD). Clinical practice guidelines recommend statin therapy for people with DM ages 40 to 75  years. The evidence for those greater than 75 years of age is relatively limited at present. Other health problems should be considered when planning ASCVD primary prevention in adults ages greater than 75 years with DM. Clinicians should discuss the risks and benefits of each plan with these pa tients and their caregivers.
Source: Clinics in Geriatric Medicine - Category: Geriatrics Authors: Source Type: research
CONCLUSIONS: ACS patients with DM showed weaker coronary plaque regression than their counterparts. A significant correlation between the change in LDL-C level and ΔPAV in DM patients suggested that more intensive lipid-lowering therapy is required in ACS patients with DM. PMID: 32435011 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
(Natural News) The available research on statin use and Type 2 diabetes risk provides varied results. But a recent study revealed that the cholesterol-lowering medication significantly heightens the risk of Type 2 diabetes. The study, published in Diabetes/Metabolism Research and Reviews, also showed that individuals who took statins for at least two years were at...
Source: NaturalNews.com - Category: Consumer Health News Source Type: news
Diabetes is associated with an increased mortality risk due to cardiovascular complications. Hyperglycemia-induced oxidative stress underlies these complications, leading to an impairment in endogenous nitric oxide (NO•) generation, together with reductions in NO• bioavailability and NO• responsiveness in the vasculature, platelets and myocardium. The latter impairment of responsiveness to NO•, termed NO• resistance, compromises the ability of traditional NO•-based therapeutics to improve hemodynamic status during diabetes-associated cardiovascular emergencies, such as acute myocardial infarct...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Use of polypills combining multiple pharmacotherapies for cardiovascular disease prevention is a hot topic in cardiovascular medicine. In a low-resource, mostly black community in Alabama with average 12% 10-year cardiovascular disease risk, a pill combining a statin plus three blood pressure-lowering medications improved adherence and control of proximal risk factors.1 In Iran, a combination of aspirin, a statin and two anti-hypertensive drugs reduced cardiovascular disease events in a mixed primary/secondary prevention population including 11% individuals with established cardiovascular disease and 15% with diabetes, as ...
Source: The American Journal of Medicine - Category: General Medicine Authors: Tags: Commentary Source Type: research
Abstract Statins lower cholesterol and risk of cardiovascular disease. Statins can increase blood glucose and risk of new onset diabetes. It is unclear why statins can have opposing effects on lipids versus glucose. Statins have cholesterol-independent pleiotropic effects that influence both insulin and glucose control. Statin lowering of isoprenoids required for protein prenylation promotes pancreatic beta cell dysfunction and adipose tissue insulin-resistance. Protein prenylation influences immune function and statin-mediated adipose tissue insulin resistance involves the NLRP3 inflammasome and IL-1b. However, t...
Source: American Journal of Physiology. Endocrinology and Metabolism - Category: Physiology Authors: Tags: Am J Physiol Endocrinol Metab Source Type: research
We evaluated the effect of statin use on new-onset type 2 diabetes among individuals without atherosclerotic cardiovascular disease (ASCVD) using nationally representative South Korean claims data (2002 –2013, ...
Source: Cardiovascular Diabetology - Category: Cardiology Authors: Tags: Original investigation Source Type: research
We report two patients with type  1 diabetes who developed autoimmune hepatitis after the administration of statin. AbstractStatins are widely used medications for the treatment of hypercholesterolemia, as well as prevention of cardiovascular disease. We report two patients with type  1 diabetes who developed autoimmune hepatitis after the administration of statin. The first patient developed the marked elevation of liver enzymes 6 months into atorvastatin therapy. The second patient developed liver dysfunction 8 months after the initiation of rosuvastatin therapy. Liver biop sies in both patients showe...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Case Report Source Type: research
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