A comparison of bone ‐targeted exercise strategies to reduce fracture risk in middle‐aged and older men with osteopenia and osteoporosis: LIFTMOR‐M semi‐randomized controlled trial

ABSTRACTInvestigations into the effects of bone ‐targeted exercise programs on musculoskeletal health and function in men are limited. The purpose of the Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men (LIFTMOR‐M) trial was to examine the efficacy and safety of two novel, supervised, eight‐month, twice‐wee kly exercise programs in middle‐aged and older men with low BMD. Men with low proximal femur and/or LS BMD were recruited and randomized to high‐intensity progressive resistance and impact training (HiRIT) or machine‐based isometric axial compression (IAC). Intervention responses were compared with those of a non‐randomized matched control group (CON). Outcomes included: proximal femur and LS BMD; calcaneal ultrasound parameters; anthropometry; body composition; physical function (timed up‐and‐go [TUG], five‐times sit‐to‐stand [FTSTS]); muscle strength (back [BES] and leg ext ensor strength [LES]); compliance and adverse events. Ninety‐three men (67.1±7.5yrs; 82.1±11.6kg; 175.2±6.7cm; FN T‐score ‐1.6±0.6) were recruited, and randomized to HiRIT (n=34) or IAC (n=33), or allocated to CON (n=26). HiRIT effects were superior to CON for trochanteric BMD (2.8±0.8%; ‐0.1±0.9%, p=0.024), LS BMD (4.1±0.7%; 0.9±0.8%, p=0.003), broadband ultrasound attenuation (2.2±0.7%; ‐0.8±0.9%, p=0.009), stiffness index (1.6±0.9%; ‐2.0±1.1%, p=0...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research

Related Links:

Radiomic models developed using lumbar spine MRI data can be used to detect...Read more on AuntMinnie.comRelated Reading: AI assesses osteoporosis risk from x-ray, CT reports Ultrasound could help assess bone health DeepSpine AI enhances grading of lumbar spinal stenosis USPSTF reaffirms osteoporosis screening
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Radiomic models developed using lumbar spine MRI data can be used to detect...Read more on AuntMinnie.comRelated Reading: AI assesses osteoporosis risk from x-ray, CT reports Ultrasound could help assess bone health DeepSpine AI enhances grading of lumbar spinal stenosis USPSTF reaffirms osteoporosis screening
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
We present a prospective review of fracture non-unions treated with low-intensity pulsed ultrasound (LIPUS). We enrolled 66 patients during August 2016 and December 2018, 38 males and 28 females; age range 19 –85 years (average 49.2 years). All these patients were followed up to minimum 6 months. The average time of referral post-treatment for fractures was 8.2 months (range 6–18 months). Four patients were excluded due to various reasons. 39 out of 62 fractures showed successful healing with sy mptom improvement and callus formation with 67% success rate. In this case series, we noted ...
Source: Journal of Ultrasound - Category: Radiology Source Type: research
ConclusionThe application of P-EU enables the identification of a substantial proportion of women with recent non-vertebral fractures at the FLS who would not need a DXA/VFA referral because they had no osteoporosis and/or subclinical vertebral fractures. The most conservative P-EU threshold resulted in 18.3% true negative tests verified by DXA/VFA against 1% false negative test results.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
AbstractPurpose of ReviewThis review discusses imaging modalities for fracture repair assessment, with an emphasis on pragmatic clinical and translational use, best practices for implementation, and challenges and opportunities for continuing research.Recent FindingsSemiquantitative radiographic union scoring remains the clinical gold standard, but has questionable reliability as a surrogate indicator of structural bone healing, particularly in early-stage, complex, or compromised healing scenarios. Alternatively, computed tomography (CT) scanning enables quantitative assessment of callus morphometry and mechanics through ...
Source: Current Osteoporosis Reports - Category: Orthopaedics Source Type: research
ABSTRACTInvestigations into the effects of bone ‐targeted exercise programs on musculoskeletal health and function in men are limited. The purpose of the Lifting Intervention For Training Muscle and Osteoporosis Rehabilitation for Men (LIFTMOR‐M) trial was to examine the efficacy and safety of two novel, supervised, eight‐month, twice‐wee kly exercise programs in middle‐aged and older men with low BMD. Men with low proximal femur and/or LS BMD were recruited and randomized to high‐intensity progressive resistance and impact training (HiRIT) or machine‐based isometric axial compression (IAC). Intervention resp...
Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Clinical Trial Source Type: research
ConclusionHighest platelet counts within the normal range are significantly associated with osteopenia and osteoporosis in middle-aged and elderly people.
Source: Archives of Orthopaedic and Trauma Surgery - Category: Orthopaedics Source Type: research
Abstract OBJECTIVE: This is a systematic review about the effects of low-intensity pulsed ultrasound (LIPUS) on stem cells differentiation. BACKGROUND DATA: In latest studies, several types of stem cells from different sources in the body have been used. These stem cells should be strictly certified and promoted for cell therapies before medical application. Low intensity pulsed ultrasound (LIPUS) has been extensively used in treatment centers and research to promote stem cells differentiation, function and proliferation. MATERIALS AND METHODS: We searched in PubMed, Google Scholar, Medline, and Scopus d...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research
ConclusionsQUS of the calcaneus confidently out ruled low BMD in individuals with axSpA, reducing the need for onward DXA referral by up to 27%. QUS is promising as a non-invasive triage tool in the assessment of osteoporosis in adults with axSpA.Key Points•Osteoporosis is common in axial spondyloarthropathy (SpA), but evaluation of bone health is suboptimal in this population.•Quantitative ultrasound (QUS) of the calcaneus can out rule low bone mineral density in individuals with axial SpA, reducing the need for DXA assessment.•QUS is a promising non-invasive triage tool in the assessment of bone health in axial SpA.
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research
The aging process is characterized by the chronic inflammatory status called “inflammaging”, which shares major molecular and cellular features with the metabolism-induced inflammation called “metaflammation.” Metaflammation is mainly driven by overnutrition and nutrient excess, but other contributing factors are metabolic modifications related to the specific body composition (BC) changes occurring with age. The aging process is indeed characterized by an increase in body total fat mass and a concomitant decrease in lean mass and bone density, that are independent from general and physiological flu...
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
More News: Clinical Trials | Orthopaedics | Osteoporosis | Rehabilitation | Sports Medicine | Training | Ultrasound | Universities & Medical Training