DNA-binding of zinc(II) and nickel(II) salphen-like complexes extrapolated at 1  M salt concentration: Removing the ionic strength bias in physiological conditions.

DNA-binding of zinc(II) and nickel(II) salphen-like complexes extrapolated at 1 M salt concentration: Removing the ionic strength bias in physiological conditions. J Inorg Biochem. 2020 Mar 17;207:111064 Authors: Bonsignore R, Farine G, Migliore C, Gennaro G, Barone G Abstract The DNA-binding of two salphen-like metal complexes of nickel(II) (1) and zinc(II) (2) was investigated in different ionic strength solutions by absorption spectroscopy. The data analysis allowed us to obtain the values of their extrapolated DNA-binding constant in physiological conditions, with DNA-binding strength in the order Ni > Zn, and to give relative weight to the electrostatic and non-electrostatic contributions to their DNA-interaction. PMID: 32220825 [PubMed - as supplied by publisher]
Source: Journal of Inorganic Biochemistry - Category: Biochemistry Authors: Tags: J Inorg Biochem Source Type: research