Cancers, Vol. 12, Pages 828: BRCA1 Promoter Hypermethylation is Associated with Good Prognosis and Chemosensitivity in Triple-Negative Breast Cancer

In conclusion, BRCA1 promoter hypermethylation is associated with TNBC sensitivity to adjuvant chemotherapy, basal-like features and PD-L1 expression. BRCA1 IHC expression is not a good surrogate marker for promoter hypermethylation and is not independently associated with prognosis. Association between promoter hypermethylation and sensitivity to Poly(ADP-ribose) polymerase PARP inhibitors needs to be evaluated in a specific series of patients.

Source: Cancers - March 29, 2020 Category: Cancer & Oncology Authors: Jacot Lopez-Crapez Mollevi Boissi ère-Michot Simony-Lafontaine Ho-Pun-Cheung Chartron Theillet Lemoine Saffroy Lamy Guiu Tags: Article Source Type: research