Metal-Free, NIS-Induced Regioselective Iodophosphoryloxylation of Alkenes with P(O)-OH bonds.

Metal-Free, NIS-Induced Regioselective Iodophosphoryloxylation of Alkenes with P(O)-OH bonds.
Chemistry. 2020 Mar 27;:
Authors: Xiong B, Xu S, Zhu Y, Yao L, Zhou C, Liu Y, Tang KW, Wong WY
Abstract
A simple and efficient method for the regioselective iodophosphoryloxylation of alkenes with P(O)-OH bonds has been established by using NIS (N-iodosuccinimide) as the iodination reagent under transition-metal-free conditions. The present protocol is compatible with different functional groups, and suitable for various alkenes and P(O)-OH compounds. A variety of functionalized β-iodo-1-ethyl phosphinic/phosphoric acid esters are obtained in good to excellent yields, which could be further transformed to diversified building blocks for the synthesis of bioactive compounds, pharmaceuticals and functional materials .
PMID: 32220090 [PubMed - as supplied by publisher]

Source: Chemistry - March 26, 2020 Category: Chemistry Authors: Xiong B, Xu S, Zhu Y, Yao L, Zhou C, Liu Y, Tang KW, Wong WY Tags: Chemistry Source Type: research