MicroRNA-195 vector influence on the development of gradually induced hepatocellular carcinoma in murine model.

Conclusions: Intra-hepatic injection of miRNA-195 vector induced apoptotic gene expression and suppressed anti-apoptotic gene but these favorable anti-cancer effects could not counteract the inflammatory, and subsequently, the oncogenic effect probably caused by vector administration. Therefore, further studies are required to investigate the effect of miRNA in combination with anti-inflammatory medications.
PMID: 32216509 [PubMed - as supplied by publisher]

Source: Ultrastructural Pathology - March 25, 2020 Category: Pathology Authors: El-Ahwany E, Mansy SS, Zoheiry M, Mourad L, Mahmoud S, Abu-Taleb H, Hassanien M, Hassan M Tags: Ultrastruct Pathol Source Type: research