Beverly Hills Rambo
Did you know that Eddie Murphy wasn’t the original choice the play the character of Axel Foley in the movie Beverly Hills Cop? That role was actually given to Sylvester Stallone, but he couldn’t get some of the comedic elements right, so Eddie Murphy was brought in to replace him. And did you know that Clint Eastwood wasn’t going to be the original Dirty Harry? Frank Sinatra was set to play that role. Unfortunately Sinatra broke his wrist and couldn’t lift the gun, so the role went to Eastwood instead. Why couldn’t Sinatra just shoot with his other hand? Who could forget Marty McFly from Back to the Future? That role wasn’t played by Michael J. Fox initially. The movie actually started filming with Eric Stoltz in the lead role, but he was cut after a few weeks due to not being perceived as funny enough. Changing actors during production is costly, but it isn’t uncommon. Sometimes this happens very late into a production. British actress Samantha Morton completed her role for the movie Her, where she played the voice of the AI. But she was replaced by Scarlett Johansson during post production, meaning that the entire role was re-recorded. Given all the money being spent by the movie industry, you might expect that they’d get these decisions right the first time and lock everything down. But the reality is that creating a film can be an evolutionary process where decisions are made and then reconsidered along the way. ...
Authors: Messaadi N, Bayen S, Beghin L, Lefebvre JM, Colleau S, Deken V, Cottencin O, Quersin F, Descamps A, Vanhelst J Abstract BACKGROUND: Screen media usage has become increasingly commonplace in daily life with children initiating themselves to screen media at an early age. Given the high prevalence of screen viewing among children worldwide, its impact on children's health has become a cause for concern. Unfortunately, little information on the independent association between sleep habits and screen time in French children is currently available. The main aim of this study was to assess possible...
Publication date: Available online 28 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of LipidsAuthor(s): Aline Bayerle, Christian Marsching, Mariona Rabionet, Shaalee Dworski, Mustafa A. Kamani, Chandramohan Chitraju, Nina L. Gluchowski, Katlyn R. Gabriel, Silke Herzer, Richard Jennemann, Thierry Levade, Jeffrey A. Medin, Roger Sandhoff
PMID: 32464083 [PubMed - as supplied by publisher]
Conclusions: EVs from buffaloes infected with Theileria spp. were successfully isolated and characterized. This is an advance in the knowledge of host-parasite relationship that contributes to the understanding of host immune response and theileriosis evasion mechanisms. These findings may pave the way for searching new EVs candidate-markers for a better production of safe biological products derived from buffaloes.
Conclusions: JZTX-X selectively suppresses Kv4.2 and Kv4.3 potassium channe l activity in a concentration- and voltage-dependent manner and causes long-lasting mechanical hyperalgesia.
Conclusion: Our results suggest a different biochemical composition of S. polymorpha venom, based on the different effects of four venom fractions on the cells tested, according to statistical evidence. Fractions F6 and F7 caused the most important alterations.
Publication date: Available online 29 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Irsa S. Hasan, Hartzell V. Schaff, Richard C. Daly, Katherine S. King, John M. Stulak, Kevin L. Greason, Joseph A. Dearani
Publication date: Available online 29 May 2020Source: The Annals of Thoracic SurgeryAuthor(s): Takafumi Ouchi, Noriyuki Kato, Hiroaki Kato, Takatoshi Higashigawa, Hisato Ito, Ken Nakajima, Shuji Chino, Toshiya Tokui, Toru Mizumoto, Hajime Sakuma
Publication date: September 2020Source: Interdisciplinary Neurosurgery, Volume 21Author(s): Nobuya Murakami, Takato Morioka, Satoshi O. Suzuki, Nobutaka Mukae, Takafumi Shimogawa, Yoshihiro Matsuo, Takakazu Sasaguri, Masahiro Mizoguchi
Publication date: September 2020Source: Interdisciplinary Neurosurgery, Volume 21Author(s): Zachary K. Christian, Kimmo J. Hatanpaa, Richard J. Auchus, Stephen R. Hammes, Ankur R. Patel, Bruce E. Mickey