Everyday tasks impair spatiotemporal variables of gait in older adults with Parkinson's disease.

Everyday tasks impair spatiotemporal variables of gait in older adults with Parkinson's disease. Hum Mov Sci. 2020 Apr;70:102591 Authors: Yamada PA, Amaral-Felipe KM, Spinoso DH, Abreu DCC, Stroppa-Marques AEZ, Faganello-Navega FR Abstract INTRODUCTION: Although it is known that individuals with Parkinson's disease (PD) have difficulties performing dual-task activities, most of the studies have verified the effect of dual tasks on gait using tasks that are uncommon to perform while walking. However, the realization of tasks involving gait that really represents the daily activities carried out by the participants, allow us to detect real fall risk situations of individuals with PD during their gait. OBJECTIVE: Our aim was to verify the influence of daily-life dual-tasks on gait spatiotemporal variables of the older adults with PD. METHODS: 20 older adults without PD and 20 older adults with PD participated in the study. Gait kinematic was analyzed under three different conditions: walking without dual task, walking carrying bags with weight, and walking talking on the cell phone. RESULTS: Older adults with PD presented lower speed (p = .001), cadence (p = .039), and shorter step length (p = .028) than older adults without PD during walking without dual tasks. When walking while carrying bags with weight, older adults with PD had a lower speed (p 
Source: Human Movement Science - Category: Neurology Authors: Tags: Hum Mov Sci Source Type: research

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This study aimed to characterize the neurophysiological correlates of gait in the human pedunculopontine nucleus (PPN) region and the globus pallidus internus (GPi) in Parkinson’s disease (PD) cohort. Though much is known about the PPN region through animal studies, there are limited physiological recordings from ambulatory humans. The PPN has recently garnered interest as a potential deep brain stimulation (DBS) target for improving gait and freezing of gait (FoG) in PD. We used bidirectional neurostimulators to record from the human PPN region and GPi in a small cohort of severely affected PD subjects with FoG desp...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Authors: Melchionda D, Varvara G, Perfetto D, Mascolo B, Avolio C Abstract Parkinson's disease (PD), which is not only a motor disease, is one of the most frequent neurodegenerative diseases and affects 1.5-2% of people worldwide. The role of its non motor-symptoms is of first importance on quality of life. Speech impairment is considered a part of motor impairment and is widespread in PD where most frequent speech impairment is Hypokinetic dysarthria, a disorder characterized by reduced articulation movements and phonetic monotony. Many PD patients show difficulty in accessing the lexicon related to cognitive impa...
Source: Journal of Biological Regulators and Homeostatic Agents - Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Mitochondrial dysfunction and neurodegeneration have been directly correlated in many neurodegenerative disorders. Parkinson’s disease (PD) in particular has been extensively studied in this context because of its well-characterized association with mitophagy, a selective type of autophagy that degrades mitochondria. Mitophagy is triggered by ubiquitin modification of proteins residing on the surface of mitochondria. Therefore, mitophagy is subject to suppression by deubiquitination. In recent years, many deubiquitinase enzymes (DUBs) emerged as therapeutic targets to compensate hindered mitophagy in PD. It is reason...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
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Source: Molecular Neurobiology - Category: Neurology Source Type: research
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Source: Neurology and Therapy - Category: Neurology Source Type: research
Authors: Lidstone SC, Bayley M, Lang AE Abstract INTRODUCTION: Parkinson's Disease (PD) is a chronic and slowly progressive neurodegenerative disease. Team-based care is required to address and manage the diverse array of motor and non-motor symptoms in PD and related conditions. As the evidence base for the efficacy of non-pharmacological treatment of PD is expanding, many different centers are implementing interdisciplinary models of care with allied health professionals trained in PD. AREAS COVERED: In this review, the authors outline these various models and review the evidence for multidisciplinary approaches ...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
PARKINSON'S disease symptoms develop slowly over a long period of time, and could be caused by nerve damage in the brain. One of the more common warning signs of the neurodegenerative brain condition includes a change to the number of times you pass urine each day. Are you at risk of Parkinson's disease?
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
This week I’m in conversation with Mohanalakshmi Rajakumar. I was fortunate, back in 2012 to come across Mohana’s work and her book ‘Love comes later’. She very kindly graced my Thursday Throng in an interview and since then has gone on to win several awards for her work, including Best Indie Book Award for Romance in 2013. When we talked she explained how she felt about her challenging relationship with writing and gives a fantastic insight into the inner world of the writer. One piece of advice she gave was that a would-be author needs to be very clear about why they are writing in the first place...
Source: The Hysterectomy Association - Category: OBGYN Authors: Tags: Healthy Happy Writer author interview Source Type: news
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Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
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Source: Parkinsonism and Related Disorders - Category: Neurology Authors: Source Type: research
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