The Expression of Hormone Receptors as a Gateway toward Understanding Endocrine Actions in Female Pelvic Floor Muscles.

CONCLUSION: Hormone receptor expression is the cornerstone in some hormone-based therapies, which require further detailed studies on the distribution of receptors in particular pelvic floor muscles, as well as their association with muscle effectors, involved in the alterations relevant for understanding pelvic floor disorders. PMID: 32216732 [PubMed - as supplied by publisher]
Source: Endocrine, Metabolic and Immune Disorders Drug Targets - Category: Endocrinology Authors: Tags: Endocr Metab Immune Disord Drug Targets Source Type: research

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AbstractPurpose of ReviewWe review the current literature pertaining to recommendations for selecting appropriate patients and performing a test phase for sacral neuromodulation.Recent FindingsCurrent literature reveals that this therapy can be successfully offered to patients with mild and severe forms of refractory overactive bladder, wet or dry. It can also be offered to elderly patients and patients with concurrent fecal incontinence, even in the setting of a known history of obstetric anal sphincter injury. Patients with non-obstructive urinary retention should be carefully selected with other etiologies ruled out, an...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research
ConclusionsMobilizing and repositioning a Martius labial fat pad is a feasible technique for complex recurrent urethral diverticulum repairs. The graft alone without meticulous urethral repair will not prevent diverticulum recurrence, fistula formation or stress urinary incontinence. This procedure requires experienced surgeons to minimize surgical complications and optimize outcome.
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
Dear Carol: My mom had a lot of health problems in her life, so her prescription list is long. Yet, sure enough, after her last doctor visit, she got yet one more prescription. Now, just a week after starting this new medication, she’s fallen three times. She frequently fell before, so I don’t want to jump to conclusions, but this seems extreme. Could medications cause this? Is this okay that she has so many medications? ...Dear Worried: One of the vital things that we do as caregivers is helping our older adult family members take necessary medications as prescribed, and question prescriptions that c...
Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Condition:   Stress Urinary Incontinence Intervention:   Procedure: mid-urethral sling procedure Sponsor:   Far Eastern Memorial Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stress Urinary Incontinence Interventions:   Drug: Duloxetine;   Drug: Imipramine Sponsor:   Far Eastern Memorial Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stress Urinary Incontinence Intervention:   Procedure: mid-urethral sling procedure Sponsor:   Far Eastern Memorial Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Condition:   Stress Urinary Incontinence Interventions:   Drug: Duloxetine;   Drug: Imipramine Sponsor:   Far Eastern Memorial Hospital Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
AbstractIntroduction and hypothesisShort questionnaires are important for validating the clinical diagnosis of urinary incontinence (UI). We sought to validate and culturally translate the Questionnaire for Urinary Incontinence Diagnosis (QUID) for the Brazilian Portuguese language.MethodsA cross-sectional study with 457 women (330 with urinary incontinence and 127 controls) was performed in a Southeastern Brazilian outpatient clinic. Patients answered a pilot-tested, notarized, six-item questionnaire (QUID) for internal consistency as well as a control questionnaire (ICIQ-SF and ICIQ-OAB) for construct validity. In both g...
Source: International Urogynecology Journal - Category: OBGYN Source Type: research
The simultaneous occurrence of Hirschsprung disease (HD) and anorectal malformation (ARM) is extremely rare, with only a very limited amount of cases published in the literature.Constipation is a major problem in patients operated for ARM, and biopsies from the distal rectum in patients with ARM may not show ganglion cells owing to different reasons, leading to a false positive diagnosis of HD. A pull-through procedure for HD after previous anorectoplasty for ARM always leads to fecal incontinence.
Source: Journal of Pediatric Surgery - Category: Surgery Authors: Source Type: research
Autologous pubovaginal sling is a surgical option for patients with stress urinary incontinence (SUI), either as primary treatment, or in those who have failed synthetic sling placement. It is also favourable for patients at high risk of mesh erosion, for example in those who are immunocompromised or post-radiation. This video reviews the technical considerations in performing an autologous pubovaginal sling fashioned from rectus fascia in an immunocompromised patient with multiple previous abdominal surgeries.
Source: Urology - Category: Urology & Nephrology Authors: Source Type: research
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