Hypoxia/Hif1α prevents premature neuronal differentiation of neural stem cells through the activation of Hes1
Publication date: Available online 28 March 2020Source: Stem Cell ResearchAuthor(s): Josef Večeřa, Jiřina Procházková, Veronika Šumberová, Veronika Pánská, Hana Paculová, Martina Kohutková Lánová, Jan Mašek, Dáša Bohačiaková, Emma Rachel Andersson, Jiří Pacherník
CONCLUSION: SHED combined with HBO therapy was effective for treating type 2 diabetic rats. The underlying mechanism may involve SHED-mediated increase in the proliferation and trans-differentiation of islet β -cells and decrease in pro-inflammatory cytokines and apoptosis of islets.
Publication date: Available online 2 June 2020Source: Stem Cell ResearchAuthor(s): Anna Janz, Ruping Chen, Martina Regensburger, Yuichiro Ueda, Simone Rost, Eva Klopocki, Katharina Günther, Frank Edenhofer, Henry J. Duff, Süleyman Ergün, Brenda Gerull
Publication date: Available online 2 June 2020Source: CytotherapyAuthor(s): Pranitha Kamat, Florian S. Frueh, Michelle McLuckie, Nadia Sanchez-Macedo, Petra Wolint, Nicole Lindenblatt, Jan A. Plock, Maurizio Calcagni, Johanna Buschmann
Publication date: Available online 2 June 2020Source: CytotherapyAuthor(s): LAERTIS IKONOMOU, DARCY E. WAGNER, SARAH E. GILPIN, DANIEL J. WEISS, AMY L. RYAN
Publication date: Available online 2 June 2020Source: NeuroscienceAuthor(s): Shaoting Zhou, Beiyao Gao, Chengcheng Sun, Yulong Bai, Dandan Cheng, Ye Zhang, Xutong Li, Jing Zhao, Dongsheng Xu
Authors: Gomes I, de Almeida BP, Dâmaso S, Mansinho A, Correia I, Henriques S, Cruz-Duarte R, Vilhais G, Félix P, Alves P, Corredeira P, Barbosa-Morais NL, Costa L, Casimiro S Abstract The role of RANKL-RANK pathway in progesterone-driven mammary carcinogenesis and triple negative breast cancer tumorigenesis has been well characterized. However, and despite evidences of the existence of RANK-positive hormone receptor (HR)-positive breast tumors, the implication of RANK expression in HR-positive breast cancers has not been addressed before. Here, we report that RANK pathway affects the expression of cel...
Authors: Kapoor V, Collins A, Griffith K, Ghosh S, Wong N, Wang X, Challen GA, Krambs J, Link D, Hallahan DE, Thotala D Abstract The immune system plays a vital role in cancer therapy, especially with the advent of immunotherapy. Radiation therapy induces iatrogenic immunosuppression referred to as radiation-induced lymphopenia (RIL). RIL correlates with significant decreases in the overall survival of cancer patients. Although the etiology and severity of lymphopenia are known, the mechanism(s) of RIL are largely unknown. We found that irradiation not only had direct effects on circulating lymphocytes but also had...
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Benjamin T. Dodsworth, Klas Hatje, Claas Aiko Meyer, Rowan Flynn, Sally A. Cowley
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Yuki Kobayashi, Ryuhei Hayashi, Shun Shibata, Andrew J. Quantock, Kohji Nishida
Publication date: Available online 1 June 2020Source: Stem Cell ResearchAuthor(s): Chenyu Fan, Zahir Shah, Hanif Ullah, Elena S. Philonenko, Baoyun Zhang, Ying Tan, Cuihua Wang, Jianguang Zhang, Igor M. Samokhvalov