Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer.

Heavy metals interfere with plasma metabolites, including lipids and amino acids, in patients with breast cancer. Oncol Lett. 2020 Apr;19(4):2925-2933 Authors: Li L, Zhang M, Men Y, Wang W, Zhang W Abstract The aim of the present study was to examine the association between plasma heavy metals and the metabolome in patients with breast cancer (BC), and the association with cancer development. Nuclear magnetic resonance was used to determine the metabolites involved and an inductively coupled plasma mass spectrometry system was used to quantify the heavy metals in the plasma samples. It was indicated that cadmium was significantly higher in the plasma of patients with BC compared with that in the control population (~15-fold increase). Chromium, arsenic and lead were also elevated in the plasma of patients with BC by ~3.24, 2.14 and 1.52 fold, respectively. A number of small molecules, including amino acids and salts, were altered in the plasma of patients with BC compared with the control population. Another notable finding in this investigation was that plasma lipid levels were elevated in patients with BC compared with those in the control population. The findings of the present study suggest that exposure to heavy metals, including cadmium, arsenic, chromium and lead, may influence blood lipid levels and other small molecule metabolites, which in turn may be involved in BC development. Further studies surrounding urinary heavy metals and the metabolome...
Source: Oncology Letters - Category: Cancer & Oncology Tags: Oncol Lett Source Type: research

Related Links:

Publication date: Available online 30 May 2020Source: Biochimica et Biophysica Acta (BBA) - Molecular Cell ResearchAuthor(s): Deborah Delbue, Bruna S. Mendonça, Marcela C. Robaina, Lauana G.T. Lemos, Pedro I. Lucena, João P.B. Viola, Lídia M. Magalhães, Susanne Crocamo, Caio A.B. Oliveira, Felipe R. Teixeira, Raquel C. Maia, Gabriela Nestal de Moraes
Source: Biochimica et Biophysica Acta (BBA) Molecular Cell Research - Category: Molecular Biology Source Type: research
Publication date: Available online 31 May 2020Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Camila A.P. Monteiro, Aline D.P.R. Oliveira, Ryan C. Silva, Rennan R.M. Lima, Fabricio O. Souto, Mariana O. Baratti, Hernandes F. Carvalho, Beate S. Santos, Paulo E. Cabral Filho, Adriana Fontes
Source: Journal of Photochemistry and Photobiology B: Biology - Category: Speech-Language Pathology Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Aoife Sartini-Bhreathnach, Edward Murphy, Siun Walsh, Malcolm Kell, Mitchell Barry, Claire Smith, Maurice Stokes
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Rebecca L. Wilson, George Boundouki, Julia R. Henderson, Paula Duxbury, James R. Harvey, Julie Wray, Rajiv Dave, Cliona C. Kirwan
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Vicki Kiesel, Gordon Wishart
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Katherine Fairhurst, Richard Swan, Charlotte Grant, Nicola Laurence
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Eleanor Walder, Elizabeth Cox
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Robyn Reddington, Morgan Galer, Amanda Hagedorn, Ehab Husain, Ravi Sharma, Valerie Speirs, Yazan Masannat
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Natalia Roszkowski, Selina Lam, Ellen Copson, Ramsey Cutress, Rachel Oeppen
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Publication date: June 2020Source: European Journal of Surgical Oncology, Volume 46, Issue 6Author(s): Rudradeep Banerjee, Diptendra Kumar Sarkar
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
More News: Breast Cancer | Cancer | Cancer & Oncology | Chromium | Study